Periodontal Therapy in a Primary Prevention of Cardiovascular Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2014-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Cardiovascular diseases (CVD) are still considered the main cause of mortality and morbidity all over the world. In the last years, efforts have been made to define more effective therapeutic and preventive strategies.Periodontal diseases have been considered a probable risk factor for CVD with a great amount of evidence from observational studies. Although there are some interventional studies evaluating the systemic effects of periodontal therapy, there is little information regarding the impact of periodontal treatment on the prevention of cardiovascular events. To the best of our knowledge, there are no randomized controlled trials published to date assessing the effect of periodontal therapy in primary prevention of CVD.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Intensive Periodontal Therapy on Vascular Function

NCT00327561

Periodontitis

COMPLETED PHASE3

Effects of Periodontal Therapy on Systemic Inflammation

NCT01046435

Periodontal Disease Cardiovascular Disease Type 2 Diabetes +2 more

COMPLETED NA

PMPR and Chlorhexidine on Periodontal Disease and Vascular Function

NCT07311512

Periodontal Disease (PD) Cardio Vascular Disease Oral-Systemic Link +2 more

NOT_YET_RECRUITING NA

Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis

NCT05137392

Periodontitis

COMPLETED NA

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

NCT04046237

Acute Myocardial Infarction Severe Periodontitis Carotid Atherosclerosis

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Periodontitis Coronary Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Standard Care Group

Dental therapist providing standard periodontal treatment

Group Type ACTIVE_COMPARATOR

Standard Care Group

Intervention Type OTHER

The group (TG) comprising one session of supragingival scaling followed by one to four sessions of subgingival scaling and root planing (SRP) by quadrant, under local anesthesia, in a period of 14 days.

Integrated Care Group

a combined treatment approach of Dental Therapist, Dental Hygienist, Cardiologist along with counselor

Group Type EXPERIMENTAL

Integrated Care Group

Intervention Type BEHAVIORAL

The group (TG) consisted of periodontal treatment comprising one session of supragingival scaling and personalized oral hygiene instructions, followed by one to four sessions of subgingival scaling and root planing (SRP) by quadrant, under local anesthesia, in a period of 14 days. Individuals were be followed monthly during the first 6 months. In the follow-up sessions, professional plaque removal, oral hygiene instructions, cardiac support along with counseling reinforcement were be provided.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Integrated Care Group

The group (TG) consisted of periodontal treatment comprising one session of supragingival scaling and personalized oral hygiene instructions, followed by one to four sessions of subgingival scaling and root planing (SRP) by quadrant, under local anesthesia, in a period of 14 days. Individuals were be followed monthly during the first 6 months. In the follow-up sessions, professional plaque removal, oral hygiene instructions, cardiac support along with counseling reinforcement were be provided.

Intervention Type BEHAVIORAL

Standard Care Group

The group (TG) comprising one session of supragingival scaling followed by one to four sessions of subgingival scaling and root planing (SRP) by quadrant, under local anesthesia, in a period of 14 days.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Individuals having at least 50% of their dentition with periodontal probing pocket depths N4 mm and
* With documented radiographic alveolar bone loss were included

Exclusion Criteria

* Known systemic diseases
* History and/or presence of other infections
* Systemic antibiotic treatment in the preceding 3 months
* Treatment with any medication known to affect the serum level of inflammatory markers, lipids, or BP
* Pregnant or lactating females
* Allergy to tetracyclines

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No