Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control
NCT ID: NCT02131922
Last Updated: 2014-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2009-09-30
2014-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Hygenization Treatment
Basic oral hygiene instructions Supragingival plaque removal
Dental Hygienization Treatment
Intensive Treatment
One-Stage Full-Mouth Disinfection. Scaling and root planing, four quadrants in one session. Extraction of radix relicta. Subgingival chlorhexidine (PerioKIN) (0.2%) in all pockets. Oral hygiene instructions.
Intensive Treatment
Intensive Surgical Treatment of Periodontitis
Chlorhexidine (Intensive Treatment)
Chlorhexidine (PerioKIN) (0.2%) implantation in dental pockets
Interventions
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Intensive Treatment
Intensive Surgical Treatment of Periodontitis
Dental Hygienization Treatment
Chlorhexidine (Intensive Treatment)
Chlorhexidine (PerioKIN) (0.2%) implantation in dental pockets
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Bleeding of these periodontal pockets on probing
* Have at least 20 natural teeth
* Provide informed consent and willingness to cooperate with the study protocol
* Age \>25 years old
* Absence of other significant oral infections.
* Primary Hypertension on stable treatment
Exclusion Criteria
* Hospitalization for any reason within the past 3 months; Life expectancy of \< 3 years;
* Allergic disorders; History of chronic infectious disease, Chronic Obstructive Pulmonary Disease (COPD), tuberculosis; chronic hepatitis B or C infection; interstitial pneumonitis, bronchiectasis; known chronic pericardial effusion, pleural effusion, or ascites; liver disease;
* Other known chronic inflammatory or autoimmune condition such as lupus or rheumatoid arthritis, ulcerative colitis or Crohn's disease
* Secondary hypertension (known plasma renin screening, abdominal ultrasound with doppler and other investigations)
* Non-basal cell malignancy or treated myelo or lymphoproliferative disease within the past 5 years;
* Known HIV positive; Immunizations within past 3 months
* Individual requires chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea.
* Primary pulmonary hypertension.
* Use of systemic or local steroids or immunosuppressive agents within 6 months of the inclusion.
* Individual is pregnant or nursing
* History of alcohol abuse or unwillingness to limit alcohol consumption to less than 4 drinks per week
25 Years
65 Years
ALL
No
Sponsors
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Jagiellonian University
OTHER
Responsible Party
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Tomasz Guzik
Prof. dr hab. med.
Locations
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J. Dietl Hospital, Department of Internal and Agricultural Medicine, Jagiellonian University
Krakow, , Poland
Jagiellonian University Dental Clinic
Krakow, , Poland
Countries
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Central Contacts
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Facility Contacts
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References
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Czesnikiewicz-Guzik M, Osmenda G, Siedlinski M, Nosalski R, Pelka P, Nowakowski D, Wilk G, Mikolajczyk TP, Schramm-Luc A, Furtak A, Matusik P, Koziol J, Drozdz M, Munoz-Aguilera E, Tomaszewski M, Evangelou E, Caulfield M, Grodzicki T, D'Aiuto F, Guzik TJ. Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur Heart J. 2019 Nov 1;40(42):3459-3470. doi: 10.1093/eurheartj/ehz646.
Other Identifiers
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MOMT-01A
Identifier Type: -
Identifier Source: org_study_id
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