Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:
NCT ID: NCT05874882
Last Updated: 2023-05-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
40 participants
INTERVENTIONAL
2022-12-12
2023-12-31
Brief Summary
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Detailed Description
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* Measuring the salivary cytokines (IL-6) before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay.
* Measuring the salivary RANKL before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay.
* Correlate the salivary cytokines IL-6 and salivary RANKL with clinical periodontal parameter and with each other.
* Evaluate the intervention by using Visual analog scale (VAS)- score-based questionnaire will be filled out by each participant at the end of the trial.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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control
patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
placebo mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
chlorohexidine mouthwash
patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
resveratrol mouthwash
patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
Interventions
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resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
placebo mouthwash as adjunct to scaling and root planing in periodontitis patients
patients with periodontitis will receive scaling and rootplaning and a placebo mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
1. Participants need to be systemically healthy with age \> 18 years old.
2. Not taking antibiotic and anti-inflammatory drugs in the last three months.
3. At least 20 teeth should be present
4. Should have unstable periodontitis (PPD ≥ 5 or BOP at 4mm pocket)
Exclusion Criteria
2. Those with chronic disease, immunocompromised patients, pregnant, on contraceptives or lactating women.
3. Those currently using any mouthwash.
4. Those on antibiotic therapy and anti-inflammatory medications during the study and in the last 3 months before the study.
5. Those having a history of hypersensitivity to any product used in the present study.
6. Those who are smokers or alcoholics.
7. Those who refuse to participate in the trial.
\-
18 Years
70 Years
ALL
Yes
Sponsors
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University of Baghdad
OTHER
Responsible Party
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Hadeel Mazin Akram
assistant professor
Locations
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College of Dentistry
Baghdad, None Selected, Iraq
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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744622
Identifier Type: -
Identifier Source: org_study_id
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