Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

NCT ID: NCT02071784

Last Updated: 2021-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-07-08

Study Completion Date

2016-10-24

Brief Summary

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The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Detailed Description

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Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

Conditions

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CADASIL

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance

Exclusion Criteria

* MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hugues Chabriat, MD PhD

Role: PRINCIPAL_INVESTIGATOR

INSERM and APHP

Locations

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CENIR, Hopital Pitié Salpetriere

Paris, , France

Site Status

Countries

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France

Other Identifiers

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2014-A00200-47

Identifier Type: REGISTRY

Identifier Source: secondary_id

C13-62

Identifier Type: -

Identifier Source: org_study_id

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