The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
NCT ID: NCT02059018
Last Updated: 2015-08-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2014-02-28
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Hypoxia
Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions over two examination days
COX-inhibitor
Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
Nitroglycerin
Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated
COX-inhibitor + Nitroglycerin
Combination of COX-inhibitor and nitroglycerin interventions.
Normoxia
Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions over two examination days
COX-inhibitor
Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
Nitroglycerin
Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated
COX-inhibitor + Nitroglycerin
Combination of COX-inhibitor and nitroglycerin interventions.
Interventions
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COX-inhibitor
Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
Nitroglycerin
Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated
COX-inhibitor + Nitroglycerin
Combination of COX-inhibitor and nitroglycerin interventions.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* No known systemic or ocular diseases
Exclusion Criteria
* Lung disease
* Epilepsy
* Previous ocular disease
* Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins
* Daily intake of medicine except contraceptive pills
* Pregnancy or breastfeeding
* Known allergy against any of the drugs used in the interventions
20 Years
60 Years
ALL
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Line Pedersen, MD
Role: PRINCIPAL_INVESTIGATOR
Aarhus University Hospital
Musa Kaya, stud.med
Role: PRINCIPAL_INVESTIGATOR
Aarhus University Hospital
Locations
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Department of Ophtalmology, Aarhus University Hospital
Aarhus, , Denmark
Countries
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Other Identifiers
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1-10-72-14-14
Identifier Type: OTHER
Identifier Source: secondary_id
HypNOCOX-2
Identifier Type: -
Identifier Source: org_study_id
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