Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

17 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-19

Study Completion Date

2021-01-01

Brief Summary

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This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

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Detailed Description

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The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Conditions

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Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Age 18 yrs and older
* Ability to follow study procedures and instructions in German

Exclusion Criteria

* Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
* Obesity (BMI \> 30kg/m2)
* Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
* Mental impairment leading to inability to cooperate
* Respiratory infection in the last two weeks
* Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes