Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation
NCT ID: NCT00856817
Last Updated: 2011-08-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
PHASE4
6 participants
INTERVENTIONAL
2009-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
NONE
Study Groups
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1
L-arginine treatment first, heme arginate treatment second
L-arginine + heme arginate
L-arginine first, heme arginate second three day treatment
2
Heme arginate treatment first, L-arginine treatment second
Heme arginate + L-arginine
Heme arginate first, L-arginine second three day treatment
Interventions
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L-arginine + heme arginate
L-arginine first, heme arginate second three day treatment
Heme arginate + L-arginine
Heme arginate first, L-arginine second three day treatment
Eligibility Criteria
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Inclusion Criteria
* healthy
* Quetelet Index (Body Mass Index) of 18 to 30 kg/m2
* In general, results of haematology and chemistry should be within the laboratory's reference ranges. Determinants of renal and hepatic function should be within twice the upper limit of normal range.
Exclusion Criteria
* history of smoking within the past year
* history of or current abuse of drugs, alcohol and/or solvents
* Current use of any (over the counter) medication potentially influencing heme oxygenase or the cardiovascular system
* Inability to understand the nature and extent of the trial and the procedures required
* Participation to a drug trial within 60 days prior to the first dose
* Febrile illness within 3 days before the first dose
* Heterozygosity (LS) or homozygosity (LL) with regard to the number of GT repeats in the HO-1 promoter region
18 Years
65 Years
ALL
Yes
Sponsors
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Dutch Diabetes Research Foundation
OTHER
Radboud University Medical Center
OTHER
Responsible Party
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Radboud University Nijmegen Medical Centre
Locations
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Radboud University Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands
Countries
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Other Identifiers
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HOADO
Identifier Type: -
Identifier Source: org_study_id
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