Optimization of MRI for Radiation Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-14

Study Completion Date

2023-02-09

Brief Summary

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Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

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Detailed Description

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Conditions

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Cancer Liver Cancer Brain Cancer Head &Neck Cancer Pelvis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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MRI group

Patient receives one research MRI prior to radiation treatment.

MRI Group

Intervention Type PROCEDURE

A single research MRI

Interventions

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MRI Group

A single research MRI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients ≥18 years of age
* A working diagnosis of malignancy in the liver, brain, H\&N, or pelvis
* A plan to treat with radiotherapy

Exclusion Criteria

* Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No