13-valent Pneumococcal Conjugate Vaccine Study in Adults and Children in India

NCT ID: NCT02034877

Last Updated: 2016-07-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-08-31

Study Completion Date

2015-07-31

Brief Summary

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This study is to describe the safety and immunogenicity of 13vPnC in Indian adults 50 to 65 years of age and in Indian children 6 to 17 years of age.

Detailed Description

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Conditions

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Prevention of Pneumonia and Invasive Disease Caused by the Serotypes in 13vPnC

Study Design

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Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

13-valent Pneumococcal conjugate vaccine

Intervention Type BIOLOGICAL

1 dose (0.5 mL/ pre-filed syringe) of 13vPnC administered at visit 1

Blood sample collection

Intervention Type PROCEDURE

10 mL of blood will be collected just before and approximately 1 month after vaccination.

Interventions

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13-valent Pneumococcal conjugate vaccine

1 dose (0.5 mL/ pre-filed syringe) of 13vPnC administered at visit 1

Intervention Type BIOLOGICAL

Blood sample collection

10 mL of blood will be collected just before and approximately 1 month after vaccination.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Indian adults subjects between 50 and 65 years of age and indian children between 6 and 17years of age, determined by clinical judgment to be eligible for 13vPnC vaccination.

Exclusion Criteria

Any contraindication to 13vPnC vaccination, vaccination with any pneumococcal vaccine within the last year
Minimum Eligible Age

6 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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King George Hospital

Visakhapatnam, Andhra Pradesh, India

Site Status

B. J. Medical College & Civil Hospital

Ahmedabad, Gujarat, India

Site Status

S.B.K.S Medical Institute & Research Centre

Vadodara, Gujarat, India

Site Status

M.S. Ramaiah Cliical Research Centre, M.S. Ramaiah Medical College & Hospitals

Bangalore, Karnataka, India

Site Status

M.S. Ramaiah Medical College and Hospitals

Bangalore, Karnataka, India

Site Status

Sushruta Multispeciality Hospital & Research Centre Pvt. Ltd.

Hubli, Karnataka, India

Site Status

Cheluvamba Hospital

Mysore, Karnataka, India

Site Status

Niramaya Hospital

Chinchwad Pune, Maharashtra, India

Site Status

Supe Heart & Diabetes Hospital and Research Centre

Nashik, Maharashtra, India

Site Status

Chopda Medicare and Research Centre Pvt. Ltd

Nashik, Maharashtra, India

Site Status

Medipoint Hospitals Pvt. Ltd.

Pune, Maharashtra, India

Site Status

Padmashree Dr. D. Y. Patil Medical College

Pune, Maharashtra, India

Site Status

Christian Medical College

Vellore, Tamil Nadu, India

Site Status

Samvedna Hospital

Varanasi, Uttar Pradesh, India

Site Status

Bhatia Hospital

Mumbai, , India

Site Status

Orange City Hospital and Research Institute

Nagpur, , India

Site Status

Countries

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India

References

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Solanki BB, Juergens C, Chopada MB, Supe P, Sundaraiyer V, Le Dren-Narayanin N, Cutler MW, Gruber WC, Scott DA, Schmoele-Thoma B. Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine in adults 50 to 65 years of age in India: An open-label trial. Hum Vaccin Immunother. 2017 Sep 2;13(9):2065-2071. doi: 10.1080/21645515.2017.1331796.

Reference Type DERIVED
PMID: 28881165 (View on PubMed)

Agarkhedkar S, Juergens C, Balasundaram K, Agarkhedkar S, Sundaraiyer V, Le Dren-Narayanin N, Cutler MW, Gruber WC, Scott DA, Schmoele-Thoma B; B1851140 Study Team. Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine in Children 6-17 Years of Age in India: An Open-label Trial. Pediatr Infect Dis J. 2017 Nov;36(11):e283-e285. doi: 10.1097/INF.0000000000001695.

Reference Type DERIVED
PMID: 28719496 (View on PubMed)

Related Links

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Other Identifiers

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2014-001174-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

B1851140

Identifier Type: -

Identifier Source: org_study_id

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