Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery

NCT ID: NCT02034019

Last Updated: 2020-01-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

247 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-02-28

Brief Summary

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To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and pain in subjects who have undergone cataract extraction with intra-ocular lens implantation.

Detailed Description

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Conditions

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Post Ocular Surgical Inflammation and Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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OTX-DP (Dexamethasone Punctum Plug)

Resorbable hydrogel drug delivery vehicle containing dexamethasone

Group Type ACTIVE_COMPARATOR

Dexamethasone

Intervention Type DRUG

Punctum Plug

Intervention Type DRUG

PVPP (Placebo Punctum Plug)

Resorbable hydrogel drug delivery vehicle containing no drug

Group Type PLACEBO_COMPARATOR

Punctum Plug

Intervention Type DRUG

Interventions

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Dexamethasone

Intervention Type DRUG

Punctum Plug

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Has a cataract and is expected to undergo clear corneal cataract surgery with phacoemulsification and implantation of a posterior chamber intraocular lens
* Has a potential post-operative pinhole corrected Snellen VA of at least 20/200 or better in both eyes

Exclusion Criteria

* Any intraocular inflammation in the study eye present during the screening slit lamp examination
* Score greater than "0" on the Ocular Pain Assessment in the study eye at Screening
* Any intraocular inflammation in the study eye present during the screening slit lamp examination
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ocular Therapeutix, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Project Manager

Role: STUDY_DIRECTOR

Ocular Therapeutix

Locations

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Texan Eye / Keystone Research, Ltd.

Austin, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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OTX-13-002

Identifier Type: -

Identifier Source: org_study_id

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