Multiple Rising Does Study (Subcutaneous Doses) of BI 655064 in Male and Female Patients With Chronic Primary Immune Thrombocytopenic Purpura (ITP).

NCT ID: NCT02009761

Last Updated: 2024-03-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-18

Study Completion Date

2016-04-26

Brief Summary

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BI 655064 will be administered subcutaneously once weekly in patients with immune thrombocytopenic purpura (ITP) for up to 12 weeks.

Detailed Description

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Conditions

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Purpura, Thrombocytopenic, Idiopathic

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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BI 655064 120 mg / 180 mg

The patients were administered 120 mg BI 655064 solution for subcutaneous injection q1w (once a week) subcutaneously for 4 weeks.

Patients who showed an increase in platelet count above or equal to 100 x 10\^9/L continued treatment with 120 mg BI 655064 solution for subcutaneous injection q1w for additional 8 weeks, followed by 12 weeks of follow-up.

Patients whose platelet count stayed below 100 x 10\^9/L continued treatment for 2 weeks with 180 mg BI 655064 solution for subcutaneous injection q1w followed by 120 mg BI 655064 solution for subcutaneous injection q1w for additional 6 weeks, followed by 12 weeks of follow-up.

Group Type EXPERIMENTAL

BI 655064

Intervention Type DRUG

subcutaneous injection

Interventions

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BI 655064

subcutaneous injection

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Male and female chronic immune ITP patients

Exclusion Criteria

Any treatment of ITP excluded except for a stable dose of corticosteroids (up to 20 mg)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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University of Southern California

Los Angeles, California, United States

Site Status

New York Hospital, Cornell Medical Center

New York, New York, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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1293.7

Identifier Type: -

Identifier Source: org_study_id

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