Pilot Study Evaluating the Toray Satake Balloon Thermal Ablation System for Treatment of Paroxysmal Atrial Fibrillation

NCT ID: NCT01997736

Last Updated: 2019-09-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-22

Study Completion Date

2016-06-01

Brief Summary

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The purpose of this study is to collect preliminary safety and effectiveness data evaluating the Toray Satake Balloon Thermal Ablation System (TSB)to treat subjects with symptomatic paroxysmal atrial fibrillation that is resistant to antiarrhythmic drug therapy.

Detailed Description

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Conditions

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Paroxysmal Atrial Fibrillation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ablation

Group Type EXPERIMENTAL

Ablation

Intervention Type DEVICE

Interventions

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Ablation

Intervention Type DEVICE

Other Intervention Names

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Toray Satake Balloon Thermal Ablation System

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of recurrent symptomatic paroxysmal atrial fibrillation
* ≥2 Symptomatic atrial fibrillation episodes
* At least 1 paroxysmal atrial fibrillation episode documented by an ECG or device recording system in the 6 months prior to enrollment AND
* At least 1 additional (for a total of ≥2) paroxysmal atrial fibrillation episode documented by an ECG or device recording system, OR, at a minimum, a physician's note indicating recurrent symptomatic atrial fibrillation
* No episode \>7 days
* Failed to respond to or is intolerant of ≥1 Class I, II, III or IV antiarrhythmic drug
* Able and willing to provide informed consent and Health Insurance Privacy and Portability Act (HIPAA) authorization
* Able and willing to meet all study requirements, including attending all post-ablation procedure assessments and visits

Exclusion Criteria

* Left atrium ≥50 mm
* Chronically used amiodarone in the 3 months prior to enrollment
* Previous left atrial ablation or surgical treatment for atrial fibrillation
* Left ventricular ejection fraction (LVEF) \<35 %
* New York Heart Association (NYHA) Class III or IV heart failure
* History of myocardial infarction (MI) or unstable angina in the 6 months prior to enrollment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Toray Industries (America), Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David Haines, MD

Role: PRINCIPAL_INVESTIGATOR

William Beaumont Hospitals

Locations

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William Beaumont Hospital, Royal Oak

Royal Oak, Michigan, United States

Site Status

Mount Sinai Hospital

New York, New York, United States

Site Status

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States

Site Status

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, United States

Site Status

Countries

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United States

References

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Satake S, Tanaka K, Saito S, Tanaka S, Sohara H, Hiroe Y, Miyashita Y, Takahashi S, Murakami M, Watanabe Y. Usefulness of a new radiofrequency thermal balloon catheter for pulmonary vein isolation: a new device for treatment of atrial fibrillation. J Cardiovasc Electrophysiol. 2003 Jun;14(6):609-15. doi: 10.1046/j.1540-8167.2003.02577.x.

Reference Type BACKGROUND
PMID: 12875422 (View on PubMed)

Sohara H, Satake S, Tanaka K, et al. Modification of electrophysiological properties of pulmonary veins and adjacent left atrial tissue by radiofrequency thermal balloon circumferential ablation around the pulmonary vein ostia: correlation with non-recurrence of atrial fibrillation. Journal of Arrhythmia 21(3):384-397, 2005.

Reference Type BACKGROUND

Sohara H, Takeda H, Ueno H, Oda T, Satake S. Feasibility of the radiofrequency hot balloon catheter for isolation of the posterior left atrium and pulmonary veins for the treatment of atrial fibrillation. Circ Arrhythm Electrophysiol. 2009 Jun;2(3):225-32. doi: 10.1161/CIRCEP.108.817205. Epub 2009 Apr 2.

Reference Type BACKGROUND
PMID: 19808472 (View on PubMed)

Sohara H, Satake S, Takeda H, et al. Radiofrequency hot balloon catheter ablation for the treatment of atrial fibrillation: a 3-center study in Japan. Journal of Arrhythmia 29:20-27, 2013

Reference Type BACKGROUND

Other Identifiers

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Toray America 2013-001

Identifier Type: -

Identifier Source: org_study_id

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