HeartLight Ablation in Patients With Paroxysmal Atrial Fibrillation (PAF)

NCT ID: NCT01456000

Last Updated: 2016-09-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

405 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2016-01-31

Brief Summary

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The purpose of this study is to demonstrate the safety and effectiveness of the CardioFocus Endoscopic Ablation System with Adaptive Contact (HeartLight) in the treatment of atrial fibrillation by creating electrical isolation of the pulmonary veins.

Detailed Description

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A randomized, controlled trial designed to demonstrate the safety and effectiveness of the experimental device to deliver pulmonary vein isolation as a treatment for symptomatic atrial fibrillation.

Conditions

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Paroxysmal Atrial Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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EAS-AC (HeartLight)

Treatment with the EAS-AC.

Group Type EXPERIMENTAL

EAS-AC (HeartLight)

Intervention Type DEVICE

Pulmonary vien isolation

Control Arm Ablation

Treatment with standard ablation.

Group Type ACTIVE_COMPARATOR

Control Arm Ablation

Intervention Type PROCEDURE

Treatment with standard ablation.

Interventions

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EAS-AC (HeartLight)

Pulmonary vien isolation

Intervention Type DEVICE

Control Arm Ablation

Treatment with standard ablation.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18 to 75 years.
* paroxysmal atrial fibrillation
* failure of at least one AAD
* others

Exclusion Criteria

* overall good health as established by multiple criteria
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CardioFocus

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Burke Barrett

Role: STUDY_DIRECTOR

CardioFocus, Inc. (sponsor)

Vivek Reddy, MD

Role: PRINCIPAL_INVESTIGATOR

Mt. Sinai Hospital, NYC

Andrea Natale, MD

Role: PRINCIPAL_INVESTIGATOR

Texas Cardiac Arrhythmia Research Foundation

Locations

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University of Alabama, Birmingham

Birminham, Alabama, United States

Site Status

Stanford Hospital

Palo Alto, California, United States

Site Status

Regional Cardiology Associates, Mercy General Hospital

Sacramento, California, United States

Site Status

UCSF

San Francisco, California, United States

Site Status

Pacific Heart Institute

Santa Monica, California, United States

Site Status

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Site Status

Prairie Heart Institute

Springfield, Illinois, United States

Site Status

The University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Johns Hopkins

Baltimore, Maryland, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Beaumont Hospital

Royal Oak, Michigan, United States

Site Status

Mayo Clinic Rochester/St. Mary's Hospital

Rochester, Minnesota, United States

Site Status

Mt. Sinai Hospital

New York, New York, United States

Site Status

Duke University

Durham, North Carolina, United States

Site Status

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Medical University South Carolina

Charleston, South Carolina, United States

Site Status

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, United States

Site Status

Methodist Hospital

Houston, Texas, United States

Site Status

Intermountain Medical Center

Murray, Utah, United States

Site Status

University of Virginia Health System

Charlottesville, Virginia, United States

Site Status

Sentara Cardiovascular Research Institute

Norfolk, Virginia, United States

Site Status

Countries

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United States

References

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Dukkipati SR, Cuoco F, Kutinsky I, Aryana A, Bahnson TD, Lakkireddy D, Woollett I, Issa ZF, Natale A, Reddy VY; HeartLight Study Investigators. Pulmonary Vein Isolation Using the Visually Guided Laser Balloon: A Prospective, Multicenter, and Randomized Comparison to Standard Radiofrequency Ablation. J Am Coll Cardiol. 2015 Sep 22;66(12):1350-60. doi: 10.1016/j.jacc.2015.07.036.

Reference Type DERIVED
PMID: 26383722 (View on PubMed)

Other Identifiers

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25-3002

Identifier Type: -

Identifier Source: org_study_id

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