[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]

NCT ID: NCT01994720

Last Updated: 2017-06-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

13307 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-07

Study Completion Date

2016-03-02

Brief Summary

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The primary objective of the study is to compare the effect of 90-day treatment with ticagrelor (180 mg \[two 90 mg tablets\] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-aspirin (300 mg \[three 100 mg tablets\] loading dose on Day 1 followed by 100 mg once daily maintenance dose for the remainder of the study) for the prevention of major vascular events (composite of stroke, myocardial infarction \[MI\], and death) in patients with acute ischaemic stroke or transient ischaemic attack (TIA).

Detailed Description

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Conditions

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Acute Ischaemic Stroke Transient Ischaemic Attack

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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ticagrelor

Group Type EXPERIMENTAL

ticagrelor

Intervention Type DRUG

ticagrelor, 180 mg (two tablets of 90 mg) loading dose on Day 1 followed by 90 mg twice daily.

Acetylsalicylic acid (ASA)

Group Type ACTIVE_COMPARATOR

Acetylsalicylic acid (ASA)

Intervention Type DRUG

ASA, 300 mg (three tablets of 100 mg) on Day 1, followed by 100 mg once daily.

Interventions

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ticagrelor

ticagrelor, 180 mg (two tablets of 90 mg) loading dose on Day 1 followed by 90 mg twice daily.

Intervention Type DRUG

Acetylsalicylic acid (ASA)

ASA, 300 mg (three tablets of 100 mg) on Day 1, followed by 100 mg once daily.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men or women equal or elder 40 years of age
* Either acute ischaemic stroke or high-risk TIA as defined here and randomisation occurring within 24 hours after onset of symptoms

Exclusion Criteria

* Planned use of antithrombotic therapy in addition to study medication including antiplatelets (eg, open label ASA, GPIIb/IIIa inhibitors, clopidogrel, ticlopidine, prasugrel, dipyridamole, ozagrel, cilostazol) and anticoagulants (eg, warfarin, oral thrombin and factor Xa inhibitors, bivalirudin, hirudin, argatroban, unfractionated and low molecular weight heparins). - Any history of atrial fibrillation, ventricular aneurysm or suspicion of cardioembolic pathology for TIA or stroke. - Planned carotid, cerebrovascular, or coronary revascularisation that requires halting study medication within 7 days of randomisation. - Receipt of any intravenous or intra-arterial thrombolysis or mechanical thrombectomy within 24 hours prior to randomisation - History of previous symptomatic non-traumatic intracerebral bleed at any time (asymptomatic microbleeds do not qualify), gastrointestinal (GI) bleed within the past 6 months, or major surgery within 30 days.
Minimum Eligible Age

40 Years

Maximum Eligible Age

130 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Montgomery, Alabama, United States

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Phoenix, Arizona, United States

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Fayetteville, Arkansas, United States

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Fort Smith, Arkansas, United States

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Fullerton, California, United States

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Glendale, California, United States

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Los Angeles, California, United States

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Newport, California, United States

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Oakland, California, United States

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San Diego, California, United States

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Stanford, California, United States

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Torrance, California, United States

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Englewood, Colorado, United States

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Altamonte Springs, Florida, United States

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Aventura, Florida, United States

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Boynton Beach, Florida, United States

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Bradenton, Florida, United States

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Gainesville, Florida, United States

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Hialeah, Florida, United States

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Jacksonville, Florida, United States

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Lakeland, Florida, United States

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Melbourne, Florida, United States

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Pompano Beach, Florida, United States

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Port Charlotte, Florida, United States

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Sarasota, Florida, United States

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Tampa, Florida, United States

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West Palm Beach, Florida, United States

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Weston, Florida, United States

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Columbus, Georgia, United States

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Chicago, Illinois, United States

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Evanston, Illinois, United States

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Glenview, Illinois, United States

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Harvey, Illinois, United States

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Joliet, Illinois, United States

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Park Ridge, Illinois, United States

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Springfield, Illinois, United States

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Urbana, Illinois, United States

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Anderson, Indiana, United States

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Fort Wayne, Indiana, United States

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Muncie, Indiana, United States

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Des Moines, Iowa, United States

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Iowa City, Iowa, United States

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Alexandria, Louisiana, United States

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New Orleans, Louisiana, United States

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Annapolis, Maryland, United States

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Frederick, Maryland, United States

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Boston, Massachusetts, United States

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Detroit, Michigan, United States

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Pontiac, Michigan, United States

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Royal Oak, Michigan, United States

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Southfield, Michigan, United States

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West Bloomfield, Michigan, United States

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Minneapolis, Minnesota, United States

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Robbinsdale, Minnesota, United States

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Saint Paul, Minnesota, United States

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Bridgeton, Missouri, United States

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Columbia, Missouri, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Great Falls, Montana, United States

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Helena, Montana, United States

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Omaha, Nebraska, United States

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Lebanon, New Hampshire, United States

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Bayonne, New Jersey, United States

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Edison, New Jersey, United States

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Englewood, New Jersey, United States

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Flemington, New Jersey, United States

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New Brunswick, New Jersey, United States

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Ridgewood, New Jersey, United States

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West Orange, New Jersey, United States

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Albuquerque, New Mexico, United States

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Brooklyn, New York, United States

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Buffalo, New York, United States

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New York, New York, United States

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Stony Brook, New York, United States

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Syracuse, New York, United States

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The Bronx, New York, United States

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Chapel Hill, North Carolina, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Greensboro, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Akron, Ohio, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Maumee, Ohio, United States

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Toledo, Ohio, United States

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Clackamas, Oregon, United States

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Portland, Oregon, United States

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Abington, Pennsylvania, United States

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Allentown, Pennsylvania, United States

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Doylestown, Pennsylvania, United States

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Erie, Pennsylvania, United States

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Hershey, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Providence, Rhode Island, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Sioux Falls, South Dakota, United States

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Chattanooga, Tennessee, United States

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Knoxville, Tennessee, United States

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Nashville, Tennessee, United States

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Baytown, Texas, United States

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Dallas, Texas, United States

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El Paso, Texas, United States

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Harlingen, Texas, United States

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Kingwood, Texas, United States

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Southlake, Texas, United States

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Richmond, Virginia, United States

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Roanoke, Virginia, United States

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Seattle, Washington, United States

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Huntington, West Virginia, United States

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Morgantown, West Virginia, United States

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Milwaukee, Wisconsin, United States

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Buenos Aires, , Argentina

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Capital Federal, , Argentina

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Ciudad Autónoma de Bs. As., , Argentina

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Mar del Plata, , Argentina

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Rosario, , Argentina

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San Martín, , Argentina

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Adelaide, , Australia

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Bedford Park, , Australia

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Camperdown, , Australia

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Clayton, , Australia

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Darlinghurst, , Australia

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Footscray, , Australia

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Herston, , Australia

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New Lambton Heights, , Australia

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Parkville, , Australia

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Southport, , Australia

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Sydney, , Australia

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Aalst, , Belgium

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Assebroek, , Belgium

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Bruges, , Belgium

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Brussels (Woluwé-St-Lambert), , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Salvador, , Brazil

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São José do Rio Preto, , Brazil

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São Paulo, , Brazil

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Botevgrad, , Bulgaria

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Dupnitsa, , Bulgaria

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Gotse Delchev, , Bulgaria

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Kozloduy, , Bulgaria

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Lukovit, , Bulgaria

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Pazardzhik, , Bulgaria

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Pernik, , Bulgaria

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Pleven, , Bulgaria

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Plovdiv, , Bulgaria

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Rousse, , Bulgaria

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Sandanski, , Bulgaria

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Sliven, , Bulgaria

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Sofia, , Bulgaria

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Teteven, , Bulgaria

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Yambol, , Bulgaria

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Vancouver, British Columbia, Canada

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St. John's, Newfoundland and Labrador, Canada

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London, Ontario, Canada

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Ottawa, Ontario, Canada

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Thunder Bay, Ontario, Canada

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Toronto, Ontario, Canada

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Chicoutimi, Quebec, Canada

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Greenfield Park, Quebec, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Concepción, , Chile

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Los Ángeles, , Chile

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Santiago, , Chile

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Talcahuano, , Chile

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Temuco, , Chile

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Valdivia, , Chile

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Viña del Mar, , Chile

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Baotou, , China

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Beijing, , China

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Changchun, , China

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Changsha, , China

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Chongqin, , China

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Guangzhou, , China

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Guilin, , China

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Haikou, , China

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Hangzhou, , China

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Harbin, , China

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Huai'an, , China

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Jinan, , China

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Lanzhou, , China

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Linhai, , China

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Nanjing, , China

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Ningbo, , China

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Shanghai, , China

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Shenyang, , China

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Taiyuan, , China

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Tianjin, , China

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Wenzhou, , China

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Wuhan, , China

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Xi'an, , China

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Xiamen, , China

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Yangzhou, , China

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Zhanjiang, , China

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Brno, , Czechia

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Chomutov, , Czechia

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Hradec Králové, , Czechia

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Jihlava, , Czechia

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Liberec, , Czechia

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Olomouc, , Czechia

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Ostrava, , Czechia

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Pardubice, , Czechia

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Prague, , Czechia

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Trutnov, , Czechia

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Antony, , France

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Bayonne, , France

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Bordeaux, , France

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Bourg-en-Bresse, , France

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Brest, , France

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Bron, , France

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Caen, , France

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Corbeil-Essonnes, , France

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Créteil, , France

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Dijon, , France

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La Roche-sur-Yon, , France

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Le Chesnay, , France

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Le Coudray, , France

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Lille, , France

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Nice, , France

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Paris, , France

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Pringy, , France

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Rennes, , France

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Rouen, , France

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Saint-Herblain, , France

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Saint-Priest-en-Jarez, , France

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Strasbourg, , France

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Toulouse, , France

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Tours, , France

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Altenburg, , Germany

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Bad Neustadt an der Saale, , Germany

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Berlin, , Germany

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Erlangen, , Germany

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Essen, , Germany

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Frankfurt, , Germany

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Hamburg, , Germany

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Karlsruhe, , Germany

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Kassel, , Germany

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Minden, , Germany

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Münster, , Germany

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Osnabrück, , Germany

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Wiesbaden, , Germany

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Hong Kong, , Hong Kong

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Kowloon, , Hong Kong

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Shatin, , Hong Kong

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Balassagyarmat, , Hungary

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Budapest, , Hungary

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Debrecen, , Hungary

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Győr, , Hungary

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Kistarcsa, , Hungary

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Miskolc, , Hungary

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Nagykanizsa, , Hungary

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Nyíregyháza, , Hungary

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Pécs, , Hungary

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Sopron-Balf, , Hungary

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Szekszárd, , Hungary

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Székesfehérvár, , Hungary

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Haifa, , Israel

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Holon, , Israel

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Jerusalem, , Israel

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Petah Tikva, , Israel

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Ramat Gan, , Israel

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Tel Aviv, , Israel

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Carrara, , Italy

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Città di Castello, , Italy

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Foligno, , Italy

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Genova, , Italy

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Gubbio, , Italy

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Lecco, , Italy

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Milan, , Italy

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Modena, , Italy

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Pavia, , Italy

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Perugia, , Italy

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Piacenza, , Italy

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Pisa, , Italy

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Reggio Emilia, , Italy

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Roma, , Italy

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Rozzano, , Italy

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Siena, , Italy

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Varese, , Italy

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Verona, , Italy

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Vibo Valentia, , Italy

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Aki-gun, , Japan

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Asahikawa-shi, , Japan

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Chiba, , Japan

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Chikushi-gun, , Japan

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Chikushino-shi, , Japan

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Chitose-shi, , Japan

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Daito-shi, , Japan

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Date-gun, , Japan

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Eniwa-shi, , Japan

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Fujinomiya-shi, , Japan

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Fukui-shi, , Japan

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Fukuoka, , Japan

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Fukushima, , Japan

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Fukuyama-shi, , Japan

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Gifu, , Japan

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Hachioji-shi, , Japan

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Hakodate-shi, , Japan

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Hamada-shi, , Japan

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Hanamaki-shi, , Japan

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Hatsukaichi-shi, , Japan

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Hidaka-shi, , Japan

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Higashiibaraki-gun, , Japan

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Higashiosaka-shi, , Japan

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Hitachi-shi, , Japan

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Ina-shi, , Japan

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Itami-shi, , Japan

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Izumisano, , Japan

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Izumo-shi, , Japan

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Kaga-shi, , Japan

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Kagoshima, , Japan

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Kakegawa-shi, , Japan

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Kamakura-shi, , Japan

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Kashiwazaki-shi, , Japan

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Kasuga-shi, , Japan

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Kawasaki-shi, , Japan

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Kobe, , Japan

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Kochi, , Japan

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Koga-shi, , Japan

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Komatsu-shi, , Japan

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Komoro-shi, , Japan

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Koshigaya-shi, , Japan

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Kumamoto, , Japan

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Kure-shi, , Japan

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Kurume-shi, , Japan

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Kyoto, , Japan

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Maizuru-shi, , Japan

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Marugame-shi, , Japan

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Matsudo-shi, , Japan

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Matsuyama, , Japan

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Nagano, , Japan

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Nagasaki, , Japan

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Nagoya, , Japan

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Nakano, , Japan

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Nakano-shi, , Japan

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Narita-shi, , Japan

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Nihonmatsu-shi, , Japan

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Okayama, , Japan

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Okinawa-shi, , Japan

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Onga-gun, , Japan

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Ookawa-shi, , Japan

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Osaka, , Japan

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Saga, , Japan

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Sagamihara-shi, , Japan

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Saijo-shi, , Japan

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Sakaishi, , Japan

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Sanuki-shi, , Japan

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Sapporo, , Japan

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Sayama-shi, , Japan

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Sendai, , Japan

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Shiroishi-shi, , Japan

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Shizuoka, , Japan

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Suita-shi, , Japan

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Suwa-shi, , Japan

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Tachikawa-shi, , Japan

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Takasaki-shi, , Japan

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Takayama-shi, , Japan

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Tokushima, , Japan

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Toyama, , Japan

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Toyohashi, , Japan

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Toyota-shi, , Japan

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Tsu, , Japan

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Ube-shi, , Japan

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Ueda-shi, , Japan

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Uji-shi, , Japan

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Ureshino-shi, , Japan

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Utsunomiya, , Japan

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Yokohama, , Japan

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Zentsuji-shi, , Japan

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Aguascalientes, , Mexico

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Culiacán, , Mexico

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D.F, , Mexico

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Del. Cuauhtemoc, , Mexico

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Distrito Federal, , Mexico

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Monterrey, , Mexico

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Bellavista, , Peru

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Callao, , Peru

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Cusco, , Peru

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Lima, , Peru

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Baguio City, , Philippines

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Cagayan de Oro, , Philippines

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Cebu, , Philippines

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Iloilo City, , Philippines

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Manila, , Philippines

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Pasay, , Philippines

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Pasig, , Philippines

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Quezon City, , Philippines

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Bialystok, , Poland

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Chełm, , Poland

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Działdowo, , Poland

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Gdansk, , Poland

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Gmina Końskie, , Poland

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Gryfice, , Poland

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Katowice, , Poland

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Kielce, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Lublin, , Poland

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Olsztyn, , Poland

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Ostrołęka, , Poland

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Sandomierz, , Poland

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Warsaw, , Poland

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Włocławek, , Poland

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Bucharest, , Romania

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Iași, , Romania

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Oradea, , Romania

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Sibiu, , Romania

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Târgu Mureş, , Romania

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Timișoara, , Romania

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Belgorod, , Russia

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Chelyabinsk, , Russia

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Irkutsk, , Russia

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Izhevsk, , Russia

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Kazan', , Russia

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Moscow, , Russia

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Nizhny Novgorod, , Russia

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Novosibirsk, , Russia

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Omsk, , Russia

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Perm, , Russia

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Saint Petersburg, , Russia

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Saratov, , Russia

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Ufa, , Russia

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Voronezh, , Russia

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Yaroslavl, , Russia

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Yekaterinburg, , Russia

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Levoča, , Slovakia

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Martin, , Slovakia

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Nitra, , Slovakia

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Spišská Nová Ves, , Slovakia

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Trnava, , Slovakia

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Žilina, , Slovakia

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Busan, , South Korea

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Daegu, , South Korea

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Gwangju, , South Korea

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Incheon, , South Korea

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Seongnam-si, , South Korea

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Seoul, , South Korea

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Wŏnju, , South Korea

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Albacete, , Spain

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Badalona(Barcelona), , Spain

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Barcelona, , Spain

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Girona, , Spain

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Lleida, , Spain

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Madrid, , Spain

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Pamplona, , Spain

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Santiago(A Coruña), , Spain

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Seville, , Spain

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Valencia, , Spain

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Valladolid, , Spain

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Falun, , Sweden

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Gothenburg, , Sweden

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Halmstad, , Sweden

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Karlstad, , Sweden

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Lidköping, , Sweden

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Linköping, , Sweden

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Malmo, , Sweden

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Mora, , Sweden

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Norrköping, , Sweden

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Östersund, , Sweden

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Stockholm, , Sweden

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Uppsala, , Sweden

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Västerås, , Sweden

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Aarau, , Switzerland

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Basel, , Switzerland

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Bern, , Switzerland

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Chur, , Switzerland

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Geneva, , Switzerland

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Lausanne, , Switzerland

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Lugano, , Switzerland

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Sankt Gallen, , Switzerland

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Villars-sur-Glâne, , Switzerland

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Zurich, , Switzerland

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Changhua, , Taiwan

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Chiayi City, , Taiwan

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Kaohsiung City, , Taiwan

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New Taipei City, , Taiwan

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Taichung, , Taiwan

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Tainan City, , Taiwan

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Taipei, , Taiwan

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Taoyuan Hsien, , Taiwan

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Bangkok, , Thailand

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Chon Buri, , Thailand

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Khon Kaen, , Thailand

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Muang, , Thailand

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Patumthani, , Thailand

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Rajthevi, , Thailand

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Ratchathewi, , Thailand

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Ankara, , Turkey (Türkiye)

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Antalya, , Turkey (Türkiye)

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Eskişehir, , Turkey (Türkiye)

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Istanbul, , Turkey (Türkiye)

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Izmir, , Turkey (Türkiye)

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Konya, , Turkey (Türkiye)

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Ivano-Frankivsk, , Ukraine

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Kharkiv, , Ukraine

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Kyiv, , Ukraine

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Lutsk, , Ukraine

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Lviv, , Ukraine

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Uzhhorod, , Ukraine

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Vinnytsia, , Ukraine

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Zaporizhzhya, , Ukraine

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Hanoi, , Vietnam

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Ho Chi Minh City, , Vietnam

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Hochiminh, , Vietnam

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Countries

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United States Argentina Australia Belgium Brazil Bulgaria Canada Chile China Czechia France Germany Hong Kong Hungary Israel Italy Japan Mexico Peru Philippines Poland Romania Russia Slovakia South Korea Spain Sweden Switzerland Taiwan Thailand Turkey (Türkiye) Ukraine Vietnam

References

Explore related publications, articles, or registry entries linked to this study.

Diener HC, Easton JD, Hart RG, Kasner S, Kamel H, Ntaios G. Review and update of the concept of embolic stroke of undetermined source. Nat Rev Neurol. 2022 Aug;18(8):455-465. doi: 10.1038/s41582-022-00663-4. Epub 2022 May 10.

Reference Type DERIVED
PMID: 35538232 (View on PubMed)

Evans SR, Knutsson M, Amarenco P, Albers GW, Bath PM, Denison H, Ladenvall P, Jonasson J, Easton JD, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC. Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clin Trials. 2020 Dec;17(6):617-626. doi: 10.1177/1740774520941441. Epub 2020 Jul 15.

Reference Type DERIVED
PMID: 32666831 (View on PubMed)

Cucchiara B, George DK, Kasner SE, Knutsson M, Denison H, Ladenvall P, Amarenco P, Johnston SC. Disability after minor stroke and TIA: A secondary analysis of the SOCRATES trial. Neurology. 2019 Aug 13;93(7):e708-e716. doi: 10.1212/WNL.0000000000007936. Epub 2019 Jul 11.

Reference Type DERIVED
PMID: 31296654 (View on PubMed)

Easton JD, Denison H, Evans SR, Knutsson M, Amarenco P, Albers GW, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KL, Johnston SC; SOCRATES Steering Committee and Investigators. Estimated treatment effect of ticagrelor versus aspirin by investigator-assessed events compared with judgement by an independent event adjudication committee in the SOCRATES trial. Int J Stroke. 2019 Dec;14(9):908-914. doi: 10.1177/1747493019851282. Epub 2019 May 15.

Reference Type DERIVED
PMID: 31092152 (View on PubMed)

Molina CA, Johnston SC, Ladenvall P, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Knutsson M, Minematsu K, Rother J, Wang Y, Wong KSL; SOCRATES Steering Committee and Investigators. Time to Loading Dose and Risk of Recurrent Events in the SOCRATES Trial. Stroke. 2019 Mar;50(3):675-682. doi: 10.1161/STROKEAHA.118.022675.

Reference Type DERIVED
PMID: 30776996 (View on PubMed)

Wong KSL, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Himmelmann A, Kasner SE, Knutsson M, Ladenvall P, Minematsu K, Molina CA, Wang Y, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial. Stroke. 2018 Jul;49(7):1678-1685. doi: 10.1161/STROKEAHA.118.020553. Epub 2018 Jun 18.

Reference Type DERIVED
PMID: 29915123 (View on PubMed)

Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. Stroke. 2017 Sep;48(9):2480-2487. doi: 10.1161/STROKEAHA.117.017217. Epub 2017 Jul 18.

Reference Type DERIVED
PMID: 28720658 (View on PubMed)

Easton JD, Aunes M, Albers GW, Amarenco P, Bokelund-Singh S, Denison H, Evans SR, Held P, Jahreskog M, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Circulation. 2017 Sep 5;136(10):907-916. doi: 10.1161/CIRCULATIONAHA.117.028566. Epub 2017 Jun 27.

Reference Type DERIVED
PMID: 28655834 (View on PubMed)

Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Hill MD, Jonasson J, Kasner SE, Ladenvall P, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol. 2017 Apr;16(4):301-310. doi: 10.1016/S1474-4422(17)30038-8. Epub 2017 Feb 23.

Reference Type DERIVED
PMID: 28238711 (View on PubMed)

Wang Y, Minematsu K, Wong KS, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Molina CA, Johnston SC; SOCRATES Steering Committee and Investigators. Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Stroke. 2017 Jan;48(1):167-173. doi: 10.1161/STROKEAHA.116.014891. Epub 2016 Nov 29.

Reference Type DERIVED
PMID: 27899747 (View on PubMed)

Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.

Reference Type DERIVED
PMID: 27160944 (View on PubMed)

Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Jul 7;375(1):35-43. doi: 10.1056/NEJMoa1603060. Epub 2016 May 10.

Reference Type DERIVED
PMID: 27160892 (View on PubMed)

Related Links

Other Identifiers

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2012-003895-38

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

D5134C00001

Identifier Type: -

Identifier Source: org_study_id

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