Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults

NCT ID: NCT01976039

Last Updated: 2018-04-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-07-31
• Study Completion Date: 2012-08-31

Brief Summary

Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis, and instillation the nasal cavity with saline has been used to reduce nasal inflammation in rhinitis and sinusopathies. The aim of this study was to assess the effects of RRC and RCC combined with saline (RRC+S) on nasal mucociliary clearance (MCC), mucus surface property, cellularity and airways symptoms in professional motorcyclists.

Detailed Description

Male motorcyclists (mean age 36 years) were recruited and randomly assigned to RRC or RRC+S. Subjects were assessed at baseline and 15 days after interventions for saccharin test, mucus contact angle, cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire. Data were analyzed by two-way ANOVA for repeated measures with Bonferroni´s correction. A passive monitoring-system of nitrogen dioxide was used to assess the individual air pollution exposure along the study period. The association between nitrogen dioxide and the airways outcomes was analyzed by Spearman correlation test.

Conditions

Nasal Obstruction; Exposure to Pollution

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

RRC

rhinopharyngeal retrograde clearance (RRC) isolated: First patient sits in a chair. Second: patient inhales air deeply and exhales making noise and vibration in the upper airway to facilitate swalling. Third patients finishes with another deep inhalation. This technique is new, simple to use and with no cost. No need of any material or equipment.

Group Type: OTHER

rhinopharyngeal retrograde clearance (RRC)

Intervention Type: OTHER

The rhinopharyngeal retrograde clearance is a respiratory physical therapy technique that uses a forced inspiratory maneuver to clear the nasopharynx with the aid of saline instillation

RRC+S

retrograde rhinopharyngeal retrograde clearance combined with saline instillation (RRC+S): patient sits in a chair and inhaled air and make noise and vibrate the upper airway at the same instills saline into the nare to facilitate nose washing and swalling. This technique is new, simple to use and with low cost (only saline).

Group Type: EXPERIMENTAL

rhinopharyngeal retrograde clearance (RRC)

Intervention Type: OTHER

The rhinopharyngeal retrograde clearance is a respiratory physical therapy technique that uses a forced inspiratory maneuver to clear the nasopharynx with the aid of saline instillation

Interventions

rhinopharyngeal retrograde clearance (RRC)

The rhinopharyngeal retrograde clearance is a respiratory physical therapy technique that uses a forced inspiratory maneuver to clear the nasopharynx with the aid of saline instillation

Intervention Type: OTHER

Other Intervention Names

RCC+S

Eligibility Criteria

Inclusion Criteria

• Professional motorcyclists aged 18 years to 45 years
• Minimum of one year in that occupation
• Agreement with the written informed consent

Exclusion Criteria

• Smokers
• Inability to understand and to follow commands
• Previous nasal surgery
• Respiratory infection in the previous 30 days

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role: collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

Sponsor Role: collaborator

University of Sao Paulo

OTHER

Sponsor Role: lead

Responsible Party

Naomi Kondo Nakagawa

Associate Professor of Faculdade de Medicina da Universidade de São Paulo

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Naomi K Nakagawa, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Paulo HN Saldiva, PhD

Role: STUDY_DIRECTOR

University of Sao Paulo

Locations

Universidade Federal de Minas Gerais

Belo Horizonte, Minas Gerais, Brazil

Faculdade de Medicina da Universidade de São Paulo

São Paulo, , Brazil

Countries

Brazil

References

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

PMID: 16236954 (View on PubMed)

Cancado JE, Braga A, Pereira LA, Arbex MA, Saldiva PH, Santos Ude P. [Clinical repercussions of exposure to atmospheric pollution]. J Bras Pneumol. 2006;32 Suppl 2:S5-11. doi: 10.1590/s1806-37132006000800003. Portuguese.

Reference Type: BACKGROUND

PMID: 17273599 (View on PubMed)

Brant TC, Yoshida CT, Carvalho Tde S, Nicola ML, Martins JA, Braga LM, Oliveira RC, Leyton V, Andre CS, Saldiva PH, Rubin BK, Nakagawa NK. Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists. Clinics (Sao Paulo). 2014;69(12):867-70. doi: 10.6061/clinics/2014(12)13.

Reference Type: DERIVED

PMID: 25628001 (View on PubMed)

Other Identifiers

CEP-FMUSP 211-11

Identifier Type: -

Identifier Source: org_study_id