Relationship Between Thoracic Aortic Structure Assessed B PET/CT Scan and Arterial Stiffness in Elderly Patients
NCT ID: NCT01963221
Last Updated: 2013-10-16
Study Results
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Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2010-01-31
2013-09-30
Brief Summary
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Vascular-aging is accompanied by a gradual remodeling affecting both cardiac and arterial walls. Arterial hypertension, an established cardiovascular risk factor, has been suggested to exert pro-inflammatory actions threw several biological mediators enhancing arterial stiffness. Both effects of aging and hypertension are associated with higher levels of arterial stiffness, but their respective role is not well established in the pathophysiology of arterial stiffening.
Few data are available neither on the real anatomic aortic impact of aging and hypertension on aortic compliance and ventricular function and its relationship to arterial stiffness assessed by carotid-femoral pulse wave velocity, nor on the reliability of cine phase contrast magnetic resonance imaging arterial stiffness measurements.
Recent studies using positron emission tomography imaging (PET) with 18 F fluorodeoxyglucose (FDG) has been advocated as a means of measuring arterial wall inflammation in various population referred for oncology staging. FDG uptake is correlated with the number of cardiovascular risk factors and even the risk of future cardiovascular events. This method, combined with X-ray computed tomography (CT), has also demonstrated that aortic calcifications quantified by CT and local signs of inflammation detected by FDG uptake contribute to arterial stiffness. A strong relationship between large vessels stiffening assessed by carotid-femoral pulse wave velocity measurement, aortic calcifications quantified by CT and inflammation evaluated by FDG uptake has been demonstrated.
Therefore, in the current study, we use FDG PET associated to CT to characterize aortic inflammation and aortic calcifications coupled to pulse wave velocity measurement and cardiac function in elderly individuals.
In fact, if vascular aging promoting a local inflammatory process is a risk factor for cardiovascular disease, then vascular changes assessed by non-invasive vascular imaging (MRI,FDG PET) could represent a potential target for treatment and prevention Thirty individuals ≥ 65 years of age were examined, 15 hypertensive subjects and 15 controls. Pulse wave velocity, a surrogate for aortic stiffness, was measured both by cine phase contrast magnetic resonance imaging and applanation tonometry. Brachial pulse pressure, carotid calculated pulse pressure and pulse pressure amplification (brachial to carotid ratio), predictors of cardiovascular mortality were also quantified. Thoracic aorta local inflammation and calcification were measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. Moreover, biomarkers of low grade inflammation (high-sensitivity C-reactive protein, interleukin 6 were also determined).
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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fluodeoxyglucose (18f)
fludeoxyglucose(18f)
blood sample
cardiac and aortic magnetic resonance imaging
carotid femoral pulse wave velocity
positron emission tomography
computed tomography
Interventions
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fludeoxyglucose(18f)
blood sample
cardiac and aortic magnetic resonance imaging
carotid femoral pulse wave velocity
positron emission tomography
computed tomography
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* inflammatory disease
* cancer
* all forms of secondary hypertension
* renal hepatic or pulmonary insufficiency
* absence of cardiac sinus rhythm
* diabetes mellitus
* contraindication to MRI
65 Years
ALL
Yes
Sponsors
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French Cardiology Society
OTHER
Central Hospital, Nancy, France
OTHER
Responsible Party
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Laure JOLY
MCU-PH, MD, PhD
Principal Investigators
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Laure JOLY, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Institut National de la Santé Et de la Recherche Médicale, France
Locations
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University Hospital of Nancy
Vandœuvre-lès-Nancy, , France
Countries
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References
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Joly L, Mandry D, Verger A, Labat C, Watfa G, Roux V, Karcher G, Marie PY, Benetos A. Influence of Thoracic Aortic Inflammation and Calcifications on Arterial Stiffness and Cardiac Function in Older Subjects. J Nutr Health Aging. 2016 Mar;20(3):347-54. doi: 10.1007/s12603-015-0574-0.
Other Identifiers
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CentralHNF
Identifier Type: -
Identifier Source: org_study_id