Evaluation of Granulosa Cells Function After IVF Protocols

NCT ID: NCT01946022

Last Updated: 2013-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Brief Summary

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This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the GnRH agonist protocol and the GnRH antagonist protocol.

Detailed Description

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Conditions

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Infertility In Vitro Fertilization Protocols

Keywords

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infertility ovulation induction luteal phase granulosa cells function GnRH agonist and antagonist HMG FSHr

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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GnRH Agonist

GnRH long agonist protocol of invitro fertilization

Group Type ACTIVE_COMPARATOR

randomization between the two GnRH analogues (agonist and antagonist)

Intervention Type DRUG

GnRH Antagonist

GnRH fixed antagonist protocol of in vitro fertilization

Group Type ACTIVE_COMPARATOR

randomization between the two GnRH analogues (agonist and antagonist)

Intervention Type DRUG

Interventions

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randomization between the two GnRH analogues (agonist and antagonist)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patient age limit: 39 years
* Follicle Stimulating Hormone (FSH) \< 10 micrometer (mU) / Liter
* Antral follicular count \> 12
* Regular menses (25 to 35 days)
* More than 3 oocytes after ovarian punction
* Anti Mullerian between 1 e 3 ng/ml

Exclusion Criteria

* Patients submitted to intracytoplasmatic sperm injection (ICSI)
* Ovarian mass or cyst
* Clinical / endocrine pathologies
Minimum Eligible Age

20 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hospital de Clinicas de Porto Alegre

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Projeto Cegonha

Porto Alegre, Rio Grande do Sul, Brazil

Site Status RECRUITING

Insemine

Porto Alegre, Rio Grande do Sul, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Rita d Chapon

Role: CONTACT

Phone: 5192028288

Email: [email protected]

Facility Contacts

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Rita d Chapon

Role: primary

Rita

Role: primary

Other Identifiers

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HCPA

Identifier Type: OTHER

Identifier Source: secondary_id

13-0120

Identifier Type: -

Identifier Source: org_study_id