Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty

NCT ID: NCT01943760

Last Updated: 2013-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2013-09-30

Brief Summary

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Tramadol is a centrally acting analgesic, is primarily Indicated for the treatment of acute pain, moderate to severe. The hernioplasty in children is an outpatient procedure, and the possibility of postoperative analgesia with fewer systemic adverse effects such as nausea and vomiting make the tramadol infiltration a technique of interest. There is controversy about its effectiveness.

The local effect of tramadol in hernioplasty was also studied by researchers with some better postoperative analgesia than with local anestetic .

There are few studies with administration of tramadol for hernioplasty, Which led to the interest in this study.

Detailed Description

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The primary objective of the study was to evaluate the analgesic effect of tramadol injected into the surgical incision in patients undergoing hernioplasty.

The study is a prospective, comparative, double covered. The distribution of patients in the groups was randomly drawn prior to starting the project and the groups were identified in envelopes numbered 1-40.

Criteria for inclusion and exclusion After approval by the Ethics Committee of UNIFESP and signature of consent by those responsible, and the term of assent by patients over six years, 40 children of both sexes will be evaluated, aged between 3 and 12 years who underwent hernioplasty.

Children with bleeding disorders, using analgesic or sensitivity to any drug will be excluded.

The patients will be randomly divided into one of two groups. Patients in group 1 will receive local infiltration with 2 mg / kg of tramadol diluted in 5 ml of 0.9% saline solution and 20ml of 0.9% saline solution intravenously at the end of the surgical procedure Patients in group 2 will receive 2 mg.kg-1 tramadol intravenously diluted in 20 ml of 0.9% saline solution and local infiltration with 5 mL of saline solution 0.9% at the end of the surgical procedure.

All patients will undergo general anesthesia, and will receive additional analgesia with dipyrone and morphine as needed in post operative period.

Conditions

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Children Inguinal Hernia

Keywords

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Tramadol Children Hernioplasty Wound infiltration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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tramadol wound infiltration

2 mg / kg of tramadol diluted in 5 ml of 0.9% saline solution wound infiltration 20ml of 0.9% saline solution intravenously

Group Type ACTIVE_COMPARATOR

tramadol

Intervention Type DRUG

The volume of the solution was adequate to maintain the concentration of 2% tramadol

0.9% saline

Intervention Type DRUG

tramadol intravenous administration

2 mg / kg of tramadol diluted 20ml of 0.9% saline solution intravenously 5 ml of 0.9% saline solution wound infiltration

Group Type EXPERIMENTAL

tramadol

Intervention Type DRUG

The volume of the solution was adequate to maintain the concentration of 2% tramadol

0.9% saline

Intervention Type DRUG

Interventions

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tramadol

The volume of the solution was adequate to maintain the concentration of 2% tramadol

Intervention Type DRUG

0.9% saline

Intervention Type DRUG

Other Intervention Names

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tramal

Eligibility Criteria

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Inclusion Criteria

* children of both sexes
* aged between 3 and 12 years
* underwent hernioplasty

Exclusion Criteria

* children with bleeding disorders
* using analgesic
* sensitivity to any drug.
Minimum Eligible Age

3 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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Ana Laura Albertoni Giraldes

doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ana LA Giraldes, MD

Role: PRINCIPAL_INVESTIGATOR

Federal University of São Paulo

Locations

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São Paulo Hospital

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

References

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Demiraran Y, Ilce Z, Kocaman B, Bozkurt P. Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy? Paediatr Anaesth. 2006 Oct;16(10):1047-50. doi: 10.1111/j.1460-9592.2006.01910.x.

Reference Type BACKGROUND
PMID: 16972834 (View on PubMed)

Other Identifiers

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187177

Identifier Type: -

Identifier Source: org_study_id