Observational Registry Study of Quality of Life When Treating BTcP With Abstral

NCT ID: NCT01936636

Last Updated: 2015-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

164 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2015-06-30

Brief Summary

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This Observational Registry study is designed to collect self-reported Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program-enrolled patient experience with breakthrough cancer pain (BTcP) as a result of treatment with Abstral® through the use of Quality of Life and pain measurement tools administered via questionnaire.

Detailed Description

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This is a post-marketing, single arm, open label multicenter trial to assess Abstral (fentanyl) Sublingual Tablets for breakthrough cancer pain (BTcP) in opioid-tolerant cancer patients.

* Prior to study enrollment, patient enrollment in the TIRF REMS Access program must be confirmed.
* Eligible patients will sign written informed consent. Patients or their proxy with a witness must be able to sign written informed consent to participate in the study; and the patient may use a proxy caregiver to assist in the completion of the study questionnaires.
* Day 0, study site must enroll patient by completing a patient demographic profile (de-identified).
* Day 0, patient will be instructed how to use the questionnaires.
* Day 0, patient will complete the baseline questionnaire before leaving the physician office.
* On study Days 14, 21, and 28 (±3 days) patient questionnaire will be completed by patient (or caregiver proxy) via secure online data entry portal.
* For patients completing paper questionnaires, within 1 month of day 28, patient will return completed questionnaires via mail, fax or hand carried to the study site coordinator for processing.
* Patient will be considered to have completed the study successfully once all completed questionnaires have been received by the CRO within appropriate time limits.

Conditions

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Quality of Life Breakthrough Cancer Pain

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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Cancer patients treated for BTcP

All patients 18 years of age and older with breakthrough cancer pain (BTcP) who are registered in the Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program and receiving Abstral® under the direction of a TIRF REMS Access program-registered physician are eligible for the study.

Patients or their proxy with a witness must be able to sign written informed consent to participate in the study; and the patient may also use a proxy caregiver to assist in the completion of the study questionnaires.

Fentanyl

Intervention Type DRUG

Interventions

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Fentanyl

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All patients 18 years of age and older with breakthrough cancer pain who are registered in the Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program and receiving Abstral® under the direction of a TIRF REMS Access program-registered physician are eligible for the study.

Patients or their proxy with a witness must be able to sign written informed consent to participate in the study; and the patient may also use a proxy caregiver to assist in the completion of the study questionnaires.

Exclusion Criteria

* No patient can be enrolled who has not been prescribed Abstral for BTcP in compliance with Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program guidelines.

No patient may be enrolled who has a contraindication to receiving Abstral or who is pregnant.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Galena Biopharma, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Physicians Pain Specialists of Alabama, P.C.

Mobile, Alabama, United States

Site Status

Pain Centers Nationwide

Peoria, Arizona, United States

Site Status

Valley Pain Consultants

Scottsdale, Arizona, United States

Site Status

Coastal Pain Research

Carlsbad, California, United States

Site Status

Navajo Road Pain Management Center

El Cajon, California, United States

Site Status

California Cancer Associates for Research and Excellence, Inc.

Fresno, California, United States

Site Status

Interventional Pain Management

Irvine, California, United States

Site Status

Alexander Ford, MD

Los Angeles, California, United States

Site Status

Cancer Care Institute

Los Angeles, California, United States

Site Status

Pete J. Ruane, MD, Inc.

Los Angeles, California, United States

Site Status

Pain Institute of Santa Monica

Santa Monica, California, United States

Site Status

Randy Scharlach, MD

Woodland Hills, California, United States

Site Status

Red Rocks Center for Rehabilitation

Golden, Colorado, United States

Site Status

Western Connecticut Health Network, Danbury Hospital

Danbury, Connecticut, United States

Site Status

Pain Management Associates of CT, PC

Stamford, Connecticut, United States

Site Status

Florida Cancer Care

Plantation, Florida, United States

Site Status

Interventional Spine and Pain Management

Atlanta, Georgia, United States

Site Status

Cancer Treatment Centers of America

Newnan, Georgia, United States

Site Status

Pain Management Institute

Overland Park, Kansas, United States

Site Status

Physiatry Consultants

Bay City, Michigan, United States

Site Status

Michigan Interventional Pain Center

Brownstown, Michigan, United States

Site Status

Glenn Saperstein, D.O., LLC

Saginaw, Michigan, United States

Site Status

Advanced Physical Medicine

Saint Clair Shores, Michigan, United States

Site Status

Michigan Spine & Pain

West Bloomfield, Michigan, United States

Site Status

Fountain Medical Group

New York, New York, United States

Site Status

Upper East Side Pain Medicine, P.C.

New York, New York, United States

Site Status

Comprehensive Pain Management

Syosset, New York, United States

Site Status

APWI

Williamsville, New York, United States

Site Status

Akron General Medical Center

Akron, Ohio, United States

Site Status

Cancer Treatment Centers of America

Tulsa, Oklahoma, United States

Site Status

J. Fred Stoner, MD

New Castle, Pennsylvania, United States

Site Status

Progressive Pain Solutions

Wind Gap, Pennsylvania, United States

Site Status

Jerrold Rosenberg, MD

Providence, Rhode Island, United States

Site Status

The West Clinic Comprehensive Breast Center

Germantown, Tennessee, United States

Site Status

PRIDE

Dallas, Texas, United States

Site Status

Columbia Basin Hematology & Oncology

Kennewick, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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RELIEF

Identifier Type: -

Identifier Source: org_study_id

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