OraVescent Fentanyl (OVF) for the Treatment of Breakthrough Pain in Opioid Tolerant Cancer Patients

NCT ID: NCT00105937

Last Updated: 2012-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-04-30

Study Completion Date

2006-11-30

Brief Summary

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The purpose of this study is to evaluate the long-term safety and efficacy of OraVescent fentanyl to treat breakthrough pain episodes in cancer patients who are already opioid tolerant.

Detailed Description

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The objective of this study is to determine the tolerability and safety of OraVescent fentanyl when used long term to relieve breakthrough pain in opioid tolerant cancer patients.

Conditions

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Pain Cancer

Keywords

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Cancer Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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OraVescent fentanyl citrate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18-80 years of age
* Average of 1-4 breakthrough pain episodes per day
* Opioid tolerant
* Histologically documented diagnosis of a malignant solid tumor or hematological malignancy

Exclusion Criteria

* Primary breakthrough pain is not related to cancer in any way
* Opioid or fentanyl intolerance
* Chronic obstructive pulmonary disease (COPD) or heart disease
* Sleep apnea or active brain metastases with increased cranial pressure
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cephalon

INDUSTRY

Sponsor Role lead

Locations

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Center for Pain Management

Huntsville, Alabama, United States

Site Status

Outcomes Research International

Tucson, Arizona, United States

Site Status

Arizona Clinical Research Center

Tucson, Arizona, United States

Site Status

Hot Spring Pain Clinic

Hot Springs, Arkansas, United States

Site Status

Saint Joseph's Mercy Cancer Center

Hot Springs, Arkansas, United States

Site Status

Arkansas Cancer Institute

Pine Bluff, Arkansas, United States

Site Status

City of Hope National Medical Center

Duarte, California, United States

Site Status

The Cancer Prevention and Treatment Center

Soquel, California, United States

Site Status

Northwestern Connecticut Oncology & Hematology Associates

Torrington, Connecticut, United States

Site Status

Florida Institute of Medical Research

Jacksonville, Florida, United States

Site Status

University of Florida Shands Cancer Center at Jacksonville

Jacksonville, Florida, United States

Site Status

Hematology Oncology Associates

Lake Worth, Florida, United States

Site Status

Innovative Medical Research of South Florida

Miami Shores, Florida, United States

Site Status

Gulf Coast Oncology Association

St. Petersburg, Florida, United States

Site Status

Clinical Pharmacology Services, Inc

Tampa, Florida, United States

Site Status

Palm Beach Research

West Palm Beach, Florida, United States

Site Status

Florida Medical Clinic, PA

Zephyrhills, Florida, United States

Site Status

Southeastern Gynecologic Oncology, LLC

Atlanta, Georgia, United States

Site Status

North Shore Cancer Research Association

Skokie, Illinois, United States

Site Status

Kentucky Cancer Clinic

Hazard, Kentucky, United States

Site Status

Southwest Oncology Associates

Lafayette, Louisiana, United States

Site Status

Hematology and Oncology Specialists

New Orleans, Louisiana, United States

Site Status

St. Agnes Healthcare

Baltimore, Maryland, United States

Site Status

Huron Medical Center

Port Huron, Michigan, United States

Site Status

Providence Cancer Institute

Southfield, Michigan, United States

Site Status

Bond Clinic, Inc

Rolla, Missouri, United States

Site Status

HealthCare Research, LLC

St Louis, Missouri, United States

Site Status

North Shore University Hospital

Manhasset, New York, United States

Site Status

Beth Israel Medical Center

New York, New York, United States

Site Status

The Center for Clinical Research, LLC

Winston-Salem, North Carolina, United States

Site Status

PETC Research Group, Inc.

Tulsa, Oklahoma, United States

Site Status

Oncology Associates of Oregon

Eugene, Oregon, United States

Site Status

Allegheny Pain Management, PC

Altoona, Pennsylvania, United States

Site Status

St. Mary Medical Center

Langhorne, Pennsylvania, United States

Site Status

Mohamed Haq

Pasadena, Texas, United States

Site Status

Cancer Care Centers of South Texas

San Antonio, Texas, United States

Site Status

UTHCT (ATTN: Clinical Research)

Tyler, Texas, United States

Site Status

Hunstman Cancer Institute

Salt Lake City, Utah, United States

Site Status

Palliative Care and Pain Medicine

Salt Lake City, Utah, United States

Site Status

Great Basin Clinical Research

West Point, Utah, United States

Site Status

Cancer Outreach Associates, PC

Abingdon, Virginia, United States

Site Status

MedSource Inc

Richmond, Virginia, United States

Site Status

University of Wisconsin Medical School

Madison, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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099-15

Identifier Type: -

Identifier Source: org_study_id