Sildenafil Impact on Ventricular Function in Patients With Heart Failure
NCT ID: NCT01936350
Last Updated: 2013-11-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
24 participants
INTERVENTIONAL
2013-09-30
2013-11-30
Brief Summary
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Detailed Description
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The first and second exams will be performed by the same staff. All patients will be evaluated by two, three and four chambers view. Left and right ventricle quantification analyses will be performed by Argus software.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Sildenafil
12 patients will be in this group. They will take a sildenafil 50mg.
Sildenafil
The intervention in this group is the use of sildenafil 50mg; this group will take placebo and will be evaluated by cardiac magnetic resonance before and after the oral use of the drug.
Placebo
12 patients will be in this group, they will take placebo
Placebo
This group will use placebo; this group will take placebo and will be evaluated by cardiac magnetic resonance before and after the oral use of the placebo pill.
Interventions
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Sildenafil
The intervention in this group is the use of sildenafil 50mg; this group will take placebo and will be evaluated by cardiac magnetic resonance before and after the oral use of the drug.
Placebo
This group will use placebo; this group will take placebo and will be evaluated by cardiac magnetic resonance before and after the oral use of the placebo pill.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria: patients with new diagnosed lesions during the procedure, eg pulmonary mass and important claustrophobia, low blood pressure ( systolic blood pressure \<90 mmHg or diastolic blood pressure \<60 mmHg) nitrate or nebivolol use over the last 48 hours, metallic non MRI compatible implantable devices.
18 Years
ALL
No
Sponsors
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Hospital Ana Nery
OTHER
Responsible Party
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Andre Duraes, PhD
Doctor
Principal Investigators
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Andre M Fernandes, Master
Role: STUDY_DIRECTOR
Hospital Ana Nery - Federal University of Bahia
Locations
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Hospital Ana Neri - MRI unit
Salvador, Estado de Bahia, Brazil
Countries
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References
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Fernandes AM, Andrade AC, Barroso ND, Borges IC, Carvalho-Andrade D, Rodrigues Junior ES, Guimaraes LC, Duraes AR, Borges SM, Aras Junior R. The immediate effect of sildenafil on right ventricular function in patients with heart failure measured by cardiac magnetic resonance: a randomized control trial. PLoS One. 2015 Mar 20;10(3):e0119623. doi: 10.1371/journal.pone.0119623. eCollection 2015.
Related Links
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approved by local Institutional Review Board
Other Identifiers
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05378712.0.0000.0045
Identifier Type: -
Identifier Source: org_study_id