Effect of Sildenafil on Endothelial Function

NCT ID: NCT00297544

Last Updated: 2006-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Brief Summary

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We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Detailed Description

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We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Conditions

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Impotence

Keywords

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impotence endothelial function autonomic nervous system

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

ECT

Blinding Strategy

DOUBLE

Interventions

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Viagra

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* age 40-70
* impotence
* with and without hypertension, Hypercholesteremia or DM

Exclusion Criteria

* CHF: NYHA \> II
* Stable angina: CCS \> II
* Nitrate treatment
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

Rambam Health Care Campus

OTHER

Sponsor Role lead

Principal Investigators

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Giris Jacob, Prof, MD, DSc

Role: PRINCIPAL_INVESTIGATOR

Rambam Health Care Campus

Locations

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Rambam Medical Center, Recanati Autonomic Dysfunction CTR

Haifa, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Giris Jacob, Prof., MD, DSc

Role: CONTACT

Phone: 972-4-854-2467

Email: [email protected]

Yuram Vardi, Prof., MD

Role: CONTACT

Phone: 972-4-854-2819

Email: [email protected]

Facility Contacts

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Giris Jacob, MD, DSc

Role: primary

References

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Dayan L, Greunwald I, Vardi Y, Jacob G. A new clinical method for the assessment of penile endothelial function using the flow mediated dilation with plethysmography technique. J Urol. 2005 Apr;173(4):1268-72. doi: 10.1097/01.ju.0000152290.71948.bf.

Reference Type BACKGROUND
PMID: 15758774 (View on PubMed)

Vardi Y, Appel B, Ofer Y, Greunwald I, Dayan L, Jacob G. Effect of chronic sildenafil treatment on penile endothelial function: a randomized, double-blind, placebo controlled study. J Urol. 2009 Dec;182(6):2850-5. doi: 10.1016/j.juro.2009.08.025. Epub 2009 Oct 17.

Reference Type DERIVED
PMID: 19837434 (View on PubMed)

Other Identifiers

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1777-CTIL

Identifier Type: -

Identifier Source: org_study_id