Reference Values of Circulating Endothelial Progenitor Cells

NCT ID: NCT01918969

Last Updated: 2013-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-03-31

Brief Summary

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Circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. However reference values have not yet been determined. This study is aimed to determine reference values of CD34+144+CD14- et CD34+VEGF-R2+CD14- in healthy men and women blood donors.

Detailed Description

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At the time of blood donation, 10mL of blood will be used to calculate the concentration of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- , and the ratio of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- / all circulating endothelial progenitor cells in order to determine reference values.

Conditions

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Aortic Aneurysm

Keywords

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Endothelial progenitor cells Healthy blood donors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Blood donors

Blood donors with no exclusion criteria i.e with a very low probability to have an aortic aneurysm

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Blood donors

Exclusion Criteria

* age over 65
* Arterial hypertension (treated or not)
* Vascular disease
* smoker or former smoker who stopped smoking for less than a year
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hopital Jean Minjoz

OTHER

Sponsor Role lead

Responsible Party

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Prof. Sidney Chocron

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrea Perrotti, MD

Role: PRINCIPAL_INVESTIGATOR

University of Franche-Comte; France

Pascal Morel, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Etablissement Français du Sang

Siamak Davani, MD, PhD

Role: STUDY_CHAIR

University of Franche-Comte. france

Locations

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CHU Besançon

Besançon, , France

Site Status

Countries

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France

Central Contacts

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Sidney Chocron, MD, PhD

Role: CONTACT

Phone: +33381533121

Email: [email protected]

Sidney Chocron, MD,PhD

Role: CONTACT

Phone: +33381533121

Email: [email protected]

Facility Contacts

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Sidney Chocron, MD, PhD

Role: primary

References

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Parietti E, Pallandre JR, Deschaseaux F, Aupecle B, Durst C, Kantelip JP, Chocron S, Davani S. Presence of circulating endothelial progenitor cells and levels of stromal-derived factor-1alpha are associated with ascending aorta aneurysm size. Eur J Cardiothorac Surg. 2011 Jul;40(1):e6-12. doi: 10.1016/j.ejcts.2011.02.065. Epub 2011 Apr 9.

Reference Type BACKGROUND
PMID: 21481600 (View on PubMed)

Other Identifiers

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13/408

Identifier Type: -

Identifier Source: org_study_id