Dual Time Point PET in Lymphoma

NCT ID: NCT01894945

Last Updated: 2013-07-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-03-31

Study Completion Date

2014-07-31

Brief Summary

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This study aims to investigate the value of dual time point PET/CT in lymphoma. Since FDG uptake is linked to glucose metabolism, PET imaging is also used to detect suspected sites for infectious and inflammatory disorders. In a clinical setting, it is a challenge to distinguish between FDG uptake in benign and malignant lesions and this gives rise to a considerable quantity of false positive results and decreased positive predictive values. Performing FDG-PET imaging sixty minutes after injection is common practice in the staging and surveillance of lymphoma but this procedure may not be optimal, especially not in settings where benign inflammatory lesions are of clinical concern.

In an attempt to find an alternative method for this discrimination, dual time point FDG-PET was introduced. This technique has shown itself to be a potentially promising method in FDG-PET imaging for distinguishing between malignant and benign lesions using SUV values. The reason for the different FDG uptake patterns between inflammatory and malignant lesions is unclear. Several factors may contribute to this phenomenon on a cellular basis. It has been shown that cancer cells exhibit increased numbers of glucose transporter and low level of glucose-6-phosphatase. Varying levels between different cancer cell types may explain the different FDG uptake curves. Because various cell types exhibit varying rates of FDG uptake we believe that kinetic investigation may prove to be of value in understanding different types of lymphoma and identifying how to perform precise imaging for staging and surveillance.

Detailed Description

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Conditions

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Hodgkin's and Non-Hodgkin's Lymphoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with suspected lymphoma.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age\>18 years
* Planned for curative treatment

Exclusion Criteria

* Previously treatment with chemotherapy or irradiation
* Primary CNS lymphoma
* Recurrent lymphoma
* Transformation from indolent lymphoma
* Presence of diabetes mellitus, HIV, chronic inflammatory disease or infections
* Pregnancy or lactation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Odense University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Karen Juul Mylam

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Odense University Hospital, Department of hematology

Odense, , Denmark

Site Status RECRUITING

Roskilde Hospital

Roskilde, , Denmark

Site Status NOT_YET_RECRUITING

Countries

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Denmark

Central Contacts

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Karen Juul Mylam, MD

Role: CONTACT

0045 6541 3186

Facility Contacts

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Karen Mylam, MD

Role: primary

0045 6441 3186

Lars Møller Pedersen, MD

Role: primary

Other Identifiers

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10.06b

Identifier Type: -

Identifier Source: org_study_id

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