Diffusion-weighted Magnetic Resonance Imaging in Post Therapy Patients With Lymphoma
NCT ID: NCT03969381
Last Updated: 2019-05-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2019-09-01
2022-01-30
Brief Summary
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* The investigator's objective is to compare the changes of mean Apparent Diffusion Coefficient value of the tumor with the changes of maximum Standardized Uptake Value of the tumor in positron Emission Tomography Computed Tomography in both pre and post therapy status .
Detailed Description
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The tumors rely on glucose as their substrate for energy production and replication, this metabolic information can be obtained from the 2-deoxy-2-fluoro-D-glucose Among the positron Emission Tomography Computed Tomography parameters, standardized uptake value is currently the most commonly used semi-quantitative index of 2-deoxy-2-fluoro-D-glucose metabolic rate. standardized uptake value reflects tumor glucose metabolism, and is commonly represented by the maximum standardized uptake value .2-deoxy-2-fluoro-D-glucose positron Emission Tomography Computed Tomography has been shown to be more accurate for the evaluation of the extent of disease and treatment response by providing these metabolic information in patients with malignant lymphoma .
2-deoxy-2-fluoro-D-glucose positron Emission Tomography Computed Tomography , with the advantage of being able to perform whole-body detection of malignant lesions, is considered to be the current standard of practice for the management of lymphomas; however, positron Emission Tomography Computed Tomography is expensive, time-consuming, involves exposure to ionizing radiation and is not widely available because it requires large and expensive equipment . In contrast, Magnetic Resonance Imaging provides excellent tissue contrast, high spatial resolution, detailed morphological information without the use of ionizing radiation . Diffusion-weighted Magnetic Resonance Imaging is a noninvasive technique allows visualization of diffusion properties of water molecules in biologic tissues. .
A supplemental tool in Diffusion-weighted imaging is the apparent diffusion coefficient map , acquired by post-processing of the obtained Diffusion-weighted images . apparent diffusion coefficient allows for quantitative definition of diffusion parameters (in mm2/sec) . Diffusion-weighted images with apparent diffusion coefficient mapping could provide useful functional information regarding the characterization of lymphomas .Because of their high cellularity and high nuclear-to-cytoplasm ratio .
Conditions
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Study Design
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CASE_CROSSOVER
CROSS_SECTIONAL
Study Groups
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1 lymphoma patients
pre therapy and post therapy of lymphoma patients
diffusion weighted magnetic resonance image in lymphoma
compare between result of positron emission tomography /computed tomography and diffusion weighted imaging in followup of lymphoma
Interventions
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diffusion weighted magnetic resonance image in lymphoma
compare between result of positron emission tomography /computed tomography and diffusion weighted imaging in followup of lymphoma
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
8 Years
80 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Sara Ali Gamal
principel investigator
Principal Investigators
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sara, Msc
Role: PRINCIPAL_INVESTIGATOR
Assiut University
Central Contacts
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Other Identifiers
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lymphoma
Identifier Type: -
Identifier Source: org_study_id