The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study

NCT ID: NCT01878071

Last Updated: 2014-05-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 73 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-06-30

Brief Summary

In recent years, greater emphasis has been placed on the link between oral and systemic health. Obesity, a growing medical problem worldwide, has been associated with multiple chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. With respect to the effect of obesity on periodontal health, it has been shown that obese subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth loss than individuals with normal weight. Peri-implantitis, an inflammatory condition of bacterial origin that occurs around oral implants and resembles periodontal disease, has become a serious concern for the dental profession given its increasing prevalence and challenging treatment. There is also strong evidence that individuals with a history of periodontitis are also at risk for peri-implantitis. However, knowledge about the pathogenesis and treatment of peri-implantitis is scarce. Hence, it is extremely important to understand the implications of excessive body fat on peri-implant health. Based on the current understanding on the effect of obesity on systemic and local inflammation around natural teeth, the investigators hypothesize that obesity will have a significant impact on peri-implant health by inducing an increased inflammatory response as measured by clinical as well as molecular markers of inflammation.

Conditions

Obesity; Peri-implant Inflammation; Peri-implantitis

Study Design

• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Single group cross sectional

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Adults (18 years or older)
• Currently non-smokers
• Subjects in maintenance care with adequate dental plaque control (<20% plaque index according to O'Leary et al. 1972)
• Subjects with at least one rough surface titanium oral implant in function for at least 6 months.

Exclusion Criteria

• Edentulous subjects or subjects presenting with blade-type implants and/or implants with smooth surface.
• Pregnant or nursing women
• Subjects who have taken medications that are known to alter the oral inflammatory status, such as antibiotics and anti-inflammatory agents, for 3 months prior to the study.
• Subjects with a history of aggressive periodontitis (As defined by the American Academy of Periodontology).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Osseointegration Foundation

UNKNOWN

Sponsor Role: collaborator

University of Iowa Institute of Clinical and Translational Science

UNKNOWN

Sponsor Role: collaborator

University of Iowa

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Craniofacial Clinical Research Center at the University of Iowa

Iowa City, Iowa, United States

Countries

United States

References

Koldsland OC, Scheie AA, Aass AM. Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss. J Periodontol. 2010 Feb;81(2):231-8. doi: 10.1902/jop.2009.090269.

Reference Type: BACKGROUND

PMID: 20151801 (View on PubMed)

Al-Zahrani MS, Bissada NF, Borawskit EA. Obesity and periodontal disease in young, middle-aged, and older adults. J Periodontol. 2003 May;74(5):610-5. doi: 10.1902/jop.2003.74.5.610.

Reference Type: BACKGROUND

PMID: 12816292 (View on PubMed)

Other Identifiers

UIOB01

Identifier Type: -

Identifier Source: org_study_id