NATRELLE® 410 X-Style and L-Style Breast Implants Continued Access Study

NCT ID: NCT01870869

Last Updated: 2020-06-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

1951 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-29

Study Completion Date

2015-11-30

Brief Summary

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This study is a prospective, multicenter, nonrandomized study to provide access to and evaluate the safety and effectiveness of NATRELLE® 410 Highly Cohesive Anatomically Shaped Silicone-Filled X-Style and L-Style Breast Implants for breast augmentation, reconstruction, or revision.

Detailed Description

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Conditions

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Breast Augmentation Breast Reconstruction Breast Implant Revision

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Augmentation

Women who had breast augmentation with NATRELLE® 410 implants.

Group Type EXPERIMENTAL

Anatomically shaped, silicone-filled breast implants with low height/projection or extra-full projection

Intervention Type DEVICE

Surgical implant

Reconstruction

Women who had breast reconstruction with NATRELLE® 410 implants.

Group Type EXPERIMENTAL

Anatomically shaped, silicone-filled breast implants with low height/projection or extra-full projection

Intervention Type DEVICE

Surgical implant

Revision-Augmentation

Women who had revision of previous breast augmentation with NATRELLE® 410 implants.

Group Type EXPERIMENTAL

Anatomically shaped, silicone-filled breast implants with low height/projection or extra-full projection

Intervention Type DEVICE

Surgical implant

Revision-Reconstruction

Women who had revision of previous breast reconstruction with NATRELLE® 410 implants.

Group Type EXPERIMENTAL

Anatomically shaped, silicone-filled breast implants with low height/projection or extra-full projection

Intervention Type DEVICE

Surgical implant

Interventions

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Anatomically shaped, silicone-filled breast implants with low height/projection or extra-full projection

Surgical implant

Intervention Type DEVICE

Other Intervention Names

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NATRELLE® 410 Highly Cohesive Anatomically Shaped Silicone-Filled Breast Implants (Styles FX, MX, LX, FL, ML, LL, LM, and LF)

Eligibility Criteria

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Inclusion Criteria

* Female, age 18 or older (age 22 or older for breast augmentation participants who are implanted under Protocol 410CAXL-001)
* Present with 1 or more of the following conditions:

* Primary breast augmentation (i.e., no previous breast implant surgery) indicated for participant dissatisfaction with size or shape of breast (e.g., mammary hypoplasia), asymmetry, ptosis, or aplasia
* Primary breast reconstruction (i.e., no previous breast implant surgery other than implantation of tissue expanders or contralateral augmentation for asymmetry) indicated, in the affected breast, for mastectomy for cancer, prophylactic mastectomy, or breast trauma, (resulting in mastectomy) and for the unaffected breast, contralateral asymmetry (may be performed on the date of the mastectomy or the date when permanent implants are placed in the reconstructed breast)
* Breast implant revision surgery (i.e., removal and replacement of breast implants) indicated for previous augmentation or reconstruction with silicone-filled or saline-filled breast implants
* Has adequate tissue available to cover implants

Exclusion Criteria

* Has an advanced fibrocystic disease considered to be premalignant without accompanying subcutaneous mastectomy
* Has an existing carcinoma of the breast, without mastectomy
* Has an abscess or infection in the body at the time of enrollment
* Is pregnant or nursing
* Has any disease, including uncontrolled diabetes (e.g., hemoglobin A1c (HbA1c) \> 8%), that is clinically known to impact wound healing ability
* Shows tissue characteristics that are clinically incompatible with mammaplasty, such as tissue damage resulting from radiation, inadequate tissue, compromised vascularity, or ulceration
* Has or is under treatment for any condition that may constitute an unwarranted surgical risk (e.g., unstable cardiac or pulmonary problems)
* Shows psychological characteristics that may be incompatible with the surgical procedure and the prosthesis, such as inappropriate attitude or motivation (e.g., body dysmorphic disorder)
* Is not willing to undergo further surgery for revision, if medically required
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrew Schumacher

Role: STUDY_CHAIR

Allergan

Locations

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Anthony Griffin

Beverly Hills, California, United States

Site Status

Laurence Berkowitz

Campbell, California, United States

Site Status

Mary Powers

Long Beach, California, United States

Site Status

Roy Hong

Palo Alto, California, United States

Site Status

Eric Bachelor

Pleasanton, California, United States

Site Status

Douglas Reavie

San Diego, California, United States

Site Status

Steven Teitelbaum

Santa Monica, California, United States

Site Status

Tad Heinz

Colorado Springs, Colorado, United States

Site Status

Gary Snider

Denver, Colorado, United States

Site Status

Terrence Murphy

Englewood, Colorado, United States

Site Status

Orlando De Lucia

Farmington, Connecticut, United States

Site Status

Lewis Berger

Tampa, Florida, United States

Site Status

Gerard Mosiello

Tampa, Florida, United States

Site Status

James Namnoum

Atlanta, Georgia, United States

Site Status

Peter Johnson

Des Plaines, Illinois, United States

Site Status

Stephen Madry

Elk Grove Village, Illinois, United States

Site Status

Janet Turkle

Carmel, Indiana, United States

Site Status

Bruce Van Natta

Indianapolis, Indiana, United States

Site Status

Christine Kelley-Patteson

Indianapolis, Indiana, United States

Site Status

Brad Storm

Olathe, Kansas, United States

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Julene Samuels

Louisville, Kentucky, United States

Site Status

Timothy Mickel

Monroe, Louisiana, United States

Site Status

Paul Davis

Shreveport, Louisiana, United States

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Bradley Bengtson

Grand Rapids, Michigan, United States

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John Renucci

Grand Rapids, Michigan, United States

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Steven Morris

Midland, Michigan, United States

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Charles Nathan

Chesterfield, Missouri, United States

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Herluf Lund Jr.

Chesterfield, Missouri, United States

Site Status

Patricia McGuire

Creve Coeur, Missouri, United States

Site Status

Schuyler Meltis

Hannibal, Missouri, United States

Site Status

Perry Johnson

Omaha, Nebraska, United States

Site Status

Perry Johnson

Omaha, Nebraska, United States

Site Status

Peter Hyans

Berkeley Heights, New Jersey, United States

Site Status

Isaac Starker

Florham Park, New Jersey, United States

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Peter Hetzler

Little Silver, New Jersey, United States

Site Status

Marc Alan Drimmer

Princeton, New Jersey, United States

Site Status

Caroline Glicksman

Sea Girt, New Jersey, United States

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Lloyd Gayle

New York, New York, United States

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John Sherman

New York, New York, United States

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Tracy Pfeifer

New York, New York, United States

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Robert Jacobs

Port Jefferson Station, New York, United States

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John Decorato

Staten Island, New York, United States

Site Status

Raymond Isakov

Cleveland, Ohio, United States

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Craig Colville

Toledo, Ohio, United States

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Frank Barone

Toledo, Ohio, United States

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Derek Shadid

Oklahoma City, Oklahoma, United States

Site Status

Robert Hein

Oklahoma City, Oklahoma, United States

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Mark Jewell

Eugene, Oregon, United States

Site Status

John Lettieri

Spartanburg, South Carolina, United States

Site Status

Kristina D. O'Shaughnessy

Nashville, Tennessee, United States

Site Status

Patrick Maxwell

Nashville, Tennessee, United States

Site Status

William Carpenter

Dallas, Texas, United States

Site Status

Jeffrey Friedman

Houston, Texas, United States

Site Status

Natan Yaker

Plano, Texas, United States

Site Status

William Adams

University Park, Texas, United States

Site Status

Gloria Duda

McLean, Virginia, United States

Site Status

Gavin Dry

Bellevue, Washington, United States

Site Status

Allen Gabriel

Vancouver, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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410CAXL-001

Identifier Type: -

Identifier Source: org_study_id

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