Proteomics Study of Gastric Bypass Surgery to Treat Type 2 Diabetes Mellitus
NCT ID: NCT01870713
Last Updated: 2013-06-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2010-10-31
2013-10-31
Brief Summary
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Detailed Description
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This study will enroll type 2 diabetes mellitus patients follwing Roux-en-Y gastric bypassing surgery and obese persons without type 2 diabetes surgery. The defferent expressions of serum proteins of obese persons without type 2 diabetes and type 2 diabetes patients following gastric bypassing surgery after 10 days or 3 months were detected by serum proteomics. Blood samples and urine will be taken prior to surgery, 10 days after surgery and 3 months after surgery. The long term prognosis of diabetes mellitus for 1 years and the remission rate of diabetes of patients will be evaluated.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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type 2 diabetes patients with gastric bypass surgery.
Participants who have type 2 diabetes and with decreased glucose after gastric bypass surgery.
No interventions assigned to this group
Weight matched non-operated controls
Participants who are overweight to moderately obese, and have no personal of family history of Type 1, Type 2, or Gestational Diabetes.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* age:18-65yr
* HbAlc\>8%
Exclusion Criteria
* chronic inflammatory disease
* malignant disease
* pregnancy
* prior gastric, duodenal, proximal jejunal surgery or pancreas resection
* current use of thiazolidinediones
* treatment with incretin mimetics or DPP IV inhibitors in the prior 3 months
* HbAlc\<8%
* any condition felt by the investigator to interfere with ability to complete the study
18 Years
65 Years
ALL
Yes
Sponsors
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No. 150 Central Hospital of the Chinese People Liberation Army
OTHER_GOV
Responsible Party
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Locations
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No. 150 Central hospital of Chinese People's Liberation Army
Luoyang, Henan, China
Countries
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Other Identifiers
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150CTSX001
Identifier Type: -
Identifier Source: org_study_id
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