Efficacy and Safety of Anthrax Vaccine, GC1109

NCT ID: NCT01867957

Last Updated: 2013-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2009-12-31

Brief Summary

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1. BACKGROUND The newly developed anthrax vaccine GC1109 has been proven safe and effective in preclinical studies.
2. OBJECTIVE

\- To evaluate the immunogenicity and safety of the anthrax vaccine GC1109 in healthy male volunteers.
3. STUDY DESIGN

* single-blinded
* randomized
* placebo controlled
* phase 1 study

Detailed Description

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Conditions

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Anthrax

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Low-dose GC1109

Group Type EXPERIMENTAL

Low-dose GC1109

Intervention Type BIOLOGICAL

50ug/dose

Low-dose Placebo

Group Type PLACEBO_COMPARATOR

Low-dose Placebo

Intervention Type BIOLOGICAL

0.9% Saline 0.5 mL

High-dose GC1109

Group Type EXPERIMENTAL

High-dose GC1109

Intervention Type BIOLOGICAL

100ug/dose

High-dose Placebo

Group Type PLACEBO_COMPARATOR

High-dose Placebo

Intervention Type BIOLOGICAL

0.9% Saline 1.0 mL

Interventions

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Low-dose GC1109

50ug/dose

Intervention Type BIOLOGICAL

High-dose GC1109

100ug/dose

Intervention Type BIOLOGICAL

Low-dose Placebo

0.9% Saline 0.5 mL

Intervention Type BIOLOGICAL

High-dose Placebo

0.9% Saline 1.0 mL

Intervention Type BIOLOGICAL

Other Intervention Names

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GC1109 50ug/dose (0.5 ml) vaccination GC1109 100ug/dose (1.0 ml) vaccination 0.9% Saline 0.5 mL vaccination 0.9% Saline 1.0 mL vaccination

Eligibility Criteria

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Inclusion Criteria

1. Healthy male subjects between 18 and 45 years of age at the time of screening visit
2. 18.5kg/m2 ≤BMI \< 30kg/m2 at the time of screening visit
3. Subjects without congenital or chronic disorder

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Green Cross Corporation

INDUSTRY

Sponsor Role collaborator

LSK Global Pharma Services Co. Ltd.

UNKNOWN

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Myoung-don Oh

Professor, Division of Infectious Diseases, Department of Internal Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Myoung-don Oh, M.D.

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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GC1109_P1_v1.2

Identifier Type: -

Identifier Source: org_study_id

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