A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3111 in Healthy Adults

NCT ID: NCT04238975

Last Updated: 2020-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

213 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-14

Study Completion Date

2021-05-31

Brief Summary

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The purpose of this study is to evaluate safety and efficacy (immunogenicity) of a single dose of GC3111 versus Boostrix® vaccine among healthy adults in 19-64 years of age.

Detailed Description

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To evaluate immunogenicity of GC3111 as tetanus, diphtheria and acellular pertussis (Tdap) vaccine in healthy adults.

To evaluate safety of GC3111 in healthy adults.

Conditions

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Tetanus Diphtheria Whooping Cough

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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GC3111 Vaccine Group

Participants randomized to receive a single dose of GC3111 vaccine (Biological: GC3111 vaccine).

Group Type EXPERIMENTAL

GC3111 vaccine

Intervention Type BIOLOGICAL

0.5mL, Intramuscular

Boostrix® Vaccine Group

Participants randomized to receive a single dose of Boostrix® vaccine (Biological: Boostrix® vaccine).

Group Type ACTIVE_COMPARATOR

Boostrix® vaccine

Intervention Type BIOLOGICAL

0.5mL, Intramuscular

Interventions

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GC3111 vaccine

0.5mL, Intramuscular

Intervention Type BIOLOGICAL

Boostrix® vaccine

0.5mL, Intramuscular

Intervention Type BIOLOGICAL

Other Intervention Names

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GC3111 Boostrix®

Eligibility Criteria

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Inclusion Criteria

1. Healthy adults aged above 19 and under 64 at the time of screening
2. Subject without history of administrating vaccines including diphtheria, tetanus or whooping cough antigens within 2 years prior to administration of investigational drug
3. Subject who provided informed consent and assent forms

Exclusion Criteria

1. Subject who received vaccine within 4 weeks prior to receiving study vaccine
2. Subject who received Tdap vaccine prior to receiving study vaccine
3. Subject with chronic cough history within 12 weeks before receiving study vaccine
4. Subject who is pregnant, lactating, or of child bearing potential without using an effective method of contraception or not practicing abstinence
5. Subject who participated in any other clinical study (investigational drug/equipment) within 6 months before receiving study vaccine
6. Subject with any condition that, in the opinion of the Investigator, might interfere with the ability to comply with trial procedures
Minimum Eligible Age

19 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Green Cross Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Dah Yoon Kim

Role: CONTACT

+82-31-260-0976

Sujin Lee

Role: CONTACT

+82-31-260-0870

Other Identifiers

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GC3111_P2

Identifier Type: -

Identifier Source: org_study_id

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