The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia

NCT ID: NCT01856387

Last Updated: 2014-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-05-31

Study Completion Date

2014-05-31

Brief Summary

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Neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammation and endothelial dysfunction. In recent years, it has been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts,may have clinical utility in predicting diseases. An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literature, many studies have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases ). However, little is known about the predictive values of NLR in pregnancy complications. This study aimed to evaluate the potential predictive value of NLR in preeclampsia- eclampsia.

Detailed Description

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In recent years, have been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts, may have clinical utility in predicting diseases.

An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literatüre have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases.However, little is known about the predictive values of NLR and PLR in gestational DM, preeclampsia and the other pregnancy complications.

Retrospective data were collected for patients who was diagnosed with , preeclampsia- eclampsia, The NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count.

Conditions

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Preeclampsia Eclampsia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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normal pregnancy outcomes

do not expect poor pregnancy outcomes on normal patients

high neutrophil to lymphocyte ratio

Intervention Type BIOLOGICAL

normal neutrophil-to Lymphocyte ratio

Intervention Type OTHER

adverse pregnancy outcome

high ratio of Neutrophil / lymphocyte ratio may predict preeclampsia eclampsia

high neutrophil to lymphocyte ratio

Intervention Type BIOLOGICAL

normal neutrophil-to Lymphocyte ratio

Intervention Type OTHER

Interventions

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high neutrophil to lymphocyte ratio

Intervention Type BIOLOGICAL

normal neutrophil-to Lymphocyte ratio

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

pregnant women who developing preeclampsia eclampsia at pregnancy

Exclusion Criteria

Known chronically maternal disease multiple pregnancy older than 40 years old
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Zekai Tahir Burak Women's Health Research and Education Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ayse Kirbas

Ayse Kirbas, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ayse kirbas

Role: PRINCIPAL_INVESTIGATOR

Zekai Tahir Burak Women's Health Research and Education Hospital

Locations

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Zekai Tahir Burak Maternity Teaching Hospital

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Facility Contacts

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ayse kirbas

Role: primary

+ 90 0 533 646 92 13

ali ersoy

Role: backup

+ 90 312-306-5000

Other Identifiers

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Zekai Tahir Burak

Identifier Type: -

Identifier Source: org_study_id

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