Dim Light at Night in Patients With Obstructive Sleep Apnea

NCT ID: NCT01853891

Last Updated: 2025-07-30

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-02-28
• Study Completion Date: 2018-06-01

Brief Summary

With the advent of electricity, light at night has become a ubiquitous part of our society.

The main purpose of this study is to determine whether sleeping with dim light (40 lux), the brightness of a night light) in your bedroom for 5 consecutive nights will result in increased markers of inflammation in the blood compared to sleeping in darkness during the night in patients with obstructive sleep apnea (OSA).

A secondary aim is to examine the effects on insulin sensitivity, other blood proteins, and RNA molecules as a result of sleeping with dim light. RNA molecules are substances in blood that dictate what type of proteins the body should make.

Detailed Description

The primary objective of this study is to determine whether sleeping with dLAN (40 lux) for 5 consecutive nights will result in increased markers of inflammation compared to sleeping in darkness (< 1 lux) during the night in patients with OSA. A secondary aim is to examine the effects on insulin sensitivity, adipokines, and RNA molecules.

The risks associated with this study are minimal compared to the potential benefits. Knowledge about the effects of sleeping with dim light on inflammation in patients with OSA is important and would guide future recommendations about proper sleep hygiene. This research may also guide future recommendations about light conditions in other environments such as hospital bedrooms.

Conditions

Obstructive Sleep Apnea (OSA)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

usual condition

sleep in usual room light condition for 5 nights

Group Type: NO_INTERVENTION

No interventions assigned to this group

dLAN

sleep with dim light at night for 5 nights

Group Type: EXPERIMENTAL

dim light at night

Intervention Type: OTHER

Interventions

dim light at night

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• • 18 -60 years of age.

• Willing and able to give informed consent
• AHI >10 episodes per hour based on a prior PSG.
• Patients who have been started on treatment for OSA with either Continuous Positive Airway Pressure (CPAP) or dental device will be eligible for the study as long as they have been compliant with treatment for at least 30 days.

Exclusion Criteria

• • Incapable of giving informed consent

• Under the age of 18
• Currently sleeping with lights on in the bedroom
• Excessive alcohol consumption

• Excessive alcohol use is defined as:
• More than 3 glasses of wine a day
• More than 3 beers a day
• More than 60 mL of hard liquor a day
• Room air oxyhemoglobin saturation < 88%
• Use of home oxygen
• Use of corticosteroids and other immunosuppressive medications.
• Diagnosis of: HIV, Connective Tissue Disease (Lupus, Rheumatoid arthritis), Inflammatory Bowel Disease.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ulysses Magalang MD

OTHER

Sponsor Role: lead

Responsible Party

Ulysses Magalang MD

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ulysses Magalnag, MD

Role: PRINCIPAL_INVESTIGATOR

Ohio State University

Locations

The Ohio State University

Columbus, Ohio, United States

Countries

United States

Other Identifiers

2012H0315

Identifier Type: -

Identifier Source: org_study_id