Molecular Screening for Lynch Syndrome in Denmark

NCT ID: NCT01845753

Last Updated: 2020-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2019-12-31

Brief Summary

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A clinically applicably strategy for molecular screening for Lynch Syndrome is being implemented in Denmark.

Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling.

The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone.

Prospective data collection is performed using established clinical databases.

Detailed Description

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Conditions

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Colorectal Cancer Lynch Syndrome HNPCC

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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All colorectal cancer patients

Observation

Intervention Type OTHER

Observation

Interventions

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Observation

Observation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Histological diagnosis of colorectal adenocarcinoma
* Diagnosed at one of the departments of pathology in Denmark

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vejle Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Pathology

Aalborg, , Denmark

Site Status

Department of Clinical Genetics

Aarhus, , Denmark

Site Status

Department of Pathology

Aarhus, , Denmark

Site Status

Department of Pathology

Esbjerg, , Denmark

Site Status

Department of Pathology

Hjørring, , Denmark

Site Status

Department of Clinical Genetics

Odense, , Denmark

Site Status

Department of Pathology

Odense, , Denmark

Site Status

Department of Pathology

Sønderborg, , Denmark

Site Status

Vejle Hospital

Vejle, , Denmark

Site Status

Department of Clinical Genetics

Vejle, , Denmark

Site Status

Department of Pathology

Vejle, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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MS-LS-DK-02

Identifier Type: -

Identifier Source: org_study_id

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