Antibiotic Prophylaxis in Bariatric Surgery With Cefazolin: Concentration in Adipose Tissue
NCT ID: NCT01845363
Last Updated: 2013-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
18 participants
INTERVENTIONAL
2011-06-30
2012-05-31
Brief Summary
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Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection.
To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
SINGLE
Study Groups
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Cefazolin
Cefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours.
Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis.
The samples were processed by High Pressure Liquid Chromatography (HPLC).
Cefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours.
Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis.
The samples were processed by HPLC.
Interventions
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Cefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours.
Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis.
The samples were processed by HPLC.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* renal disfunction (creatinine \>1.5 mg/dL)
18 Years
60 Years
ALL
No
Sponsors
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Universidade Federal de Pernambuco
OTHER
Responsible Party
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Rafael Anlicoara
Master´s degree
Principal Investigators
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Rafael Anlicoara, MD
Role: PRINCIPAL_INVESTIGATOR
UFPE
Alvaro AB Ferraz, PhD
Role: STUDY_CHAIR
UFPE - Hospital das Clínicas
José L de Lima Filho, PhD
Role: STUDY_DIRECTOR
Laboratory of Immunopathology Keiso Asami(LIKA) - UFPE
Locations
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Universidade Federal de Pernambuco - Hospital das Clínicas
Recife, Pernambuco, Brazil
Countries
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Other Identifiers
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Cefa01
Identifier Type: -
Identifier Source: org_study_id
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