Study Results
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Basic Information
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COMPLETED
70 participants
OBSERVATIONAL
2022-06-01
2024-01-31
Brief Summary
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Detailed Description
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Two anesthetic strategies were evaluated:
Opioid-Free Anesthesia (OFA): Total intravenous anesthesia (TIVA) without opioids, using agents such as propofol, ketamine, dexmedetomidine, lidocaine and magnesium.
Opioid-Based Anesthesia (OBA): TIVA including opioids, following institutional standards.
Medical records of 70 patients (35 in each group) who underwent surgery between June 2022 and December 2023 were analyzed. Key data extracted included demographics, surgical duration, anesthetic drugs used, intraoperative complications, pain scores (VAS at 1, 2, 4, 24, and 48 hours), sedation levels (RAMSAY scale), adverse effects (e.g., nausea, vomiting, ileus, hypotension), and morphine consumption.
The primary outcome is total morphine use within the first 48 hours postoperatively. Secondary outcomes include pain scores, adverse events, time to awakening, and hospital length of stay. Statistical analysis was performed using descriptive and inferential methods, including regression models adjusted for age, sex, BMI, and comorbidities.
This study provides real-world evidence on the clinical impact of opioid-free anesthesia in bariatric patients, aiming to improve perioperative safety and enhance postoperative recovery.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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OFA Group
Patients who received opioid-free total intravenous anesthesia (TIVA) for bariatric surgery, including propofol, lidocaine, ketamine, dexmedetomidine and magnesium, with no intraoperative opioids.
No interventions assigned to this group
OBA Group
Patients who received opioid-based total intravenous anesthesia (TIVA) for bariatric surgery, including propofol and intraoperative opioids such as fentanyl, remifentanil and morphine, following standard practice.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
ASA physical status II or III
Underwent laparoscopic bariatric surgery under general anesthesia at HM Nou Delfos
Surgery performed between June 1, 2022 and December 31, 2023
Exclusion Criteria
Known allergy to any anesthetic drug used in the study
Severe hepatic (e.g., cirrhosis with portal hypertension) or renal insufficiency
Untreated coagulopathy
Active alcohol or drug abuse
Uncontrolled or severe psychiatric illness
Intraoperative complications requiring deviation from planned anesthetic technique
Postoperative morphine use exceeding institutional norms for bariatric surgery
18 Years
65 Years
ALL
No
Sponsors
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Hospital HM Nou Delfos
OTHER
Responsible Party
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HIPÓLITO LABANDEYRA GONZALEZ
Anesthesiologist
Principal Investigators
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Gregory Contreras-Pérez, Anesthesiologist
Role: PRINCIPAL_INVESTIGATOR
Hospital HM NouDelfos
Locations
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Hospital HM Nou Delfos
Barcelona, Barcelona, Spain
Countries
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References
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Malo-Manso A, Ramirez-Aliaga M, Sepulveda-Haro E, Diaz-Crespo J, Escalona-Belmonte JJ, Guerrero-Orriach JL. Opioid-free anesthesia for open radical cystectomy in morbid obesity. Rev Esp Anestesiol Reanim (Engl Ed). 2021 Sep 23:S0034-9356(21)00134-1. doi: 10.1016/j.redar.2021.03.007. Online ahead of print. English, Spanish.
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Other Identifiers
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25.04.2517-GHM
Identifier Type: -
Identifier Source: org_study_id
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