Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-03

Study Completion Date

2015-03-20

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney injury/failure in an unstable hemodynamic status. Lactate is a molecule smaller than glucose, which can pass through filtration membrane freely in CVVH. Therefore, the blood lactate concentrations would no longer reflect tissue oxygenation status in patients with unstable hemodynamic status. However, there is no prospective study evaluated the effect of CVVH on lactate removal in critically ill patients. The influence of different dose of CVVH on lactate elimination is not clear in patients with different level of serum lactate. Our study aimed to find out how the dose of CVVH effects on lactate clearance, and then re-estimate the prognostic value of lactate in critically ill patients with CVVH.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia

NCT02449382

Hypernatremia Critically Ill

UNKNOWN NA

Lactate Clearance Goal-directed Therapy in Sepsis

NCT03256461

Sepsis

UNKNOWN NA

Fluid Management Surgical Patients in Intensive Care Unit.

NCT03455296

Post Operative Fluid Management

COMPLETED NA

Feasibility of Lactate Level Evaluation in Prehospital Care in Trauma

NCT03115970

Trauma, Multiple Lactate Blood Increase

UNKNOWN

Lactate Metabolism in the Hypoperfused Critically Ill

NCT05582824

Lactate Metabolism Hypoperfusion +2 more

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Kidney Injury, Acute

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Plasma lactate were measured

Three different doses (20 ml/kg/h, 35 ml/kg/h and 45 ml/kg/h) of CVVH were applied to critically ill patients who experiencing CVVH. Each dose of CVVH was sequentially gave to each patient and lasted for 30 minutes separately

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. The critical ill patients with acute kidney injury
2. Patients requiring continuous veno-venous hemofiltration
3. APACHE II scores more than 12
4. Arterial lactate is higher than 0.5mmol/L but lower than 15mmol/L (due to the sensitivity and optimal measuring range of the equipment)
5. Continuous veno-venous hemofiltration for at least 12 hrs
6. Hemo-filter age of \<24 hrs