Endomysial Fibrosis, Muscular Inflammatory Response and Calcium Homeostasis Dysfunction in Duchenne Muscular Dystrophy
NCT ID: NCT01823783
Last Updated: 2020-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2012-11-07
2021-01-31
Brief Summary
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Another crucial pathophysiological pathway in DMD is muscle cell calcium homeostasis, particularly via the ryanodine recepteur (RyR1).
Our study focus on the relationship between endomysial fibrosis, abnormal inflammation response and calcium homeostasis dysfunction which are not entirely established in DMD.
The identification of the biological mechanisms that play a role in the severity of the phenotype, particularly endomysial fibrosis, should allow the development of targeted pharmacotherapy as a complementary strategy for the future treatment of DMD.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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DMD infant
Muscle biopsy
Muscle biopsy
Muscle biopsy
Control infant
Muscle biopsy (during lower limb operation surgery for pure orthopedic causes)
Muscle biopsy
Muscle biopsy
Interventions
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Muscle biopsy
Muscle biopsy
Eligibility Criteria
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Inclusion Criteria
* Lack of any infectious disease in the last week before the study.
* Consent form signed by parents.
* Clinical suspicion of Duchenne Muscular Dystrophy
* Lack of any antecedent of congenital cardiac, pulmonary or muscular disease including DMD.
Exclusion Criteria
* Parents of the subject unable or unwilling to undergo informed consent
* Subject with no rights from the national health insurance programme
2 Years
15 Years
ALL
Yes
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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François RIVIER, PU PH
Role: PRINCIPAL_INVESTIGATOR
uh montpellier
Locations
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UH Bordeaux
Bordeaux, , France
UH Lille
Lille, , France
Montpellier University Hospital
Montpellier, , France
Necker Hospital
Paris, , France
UH Reims
Reims, , France
UH Saint Etienne
Saint-Etienne, , France
UH Toulouse
Toulouse, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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8948
Identifier Type: -
Identifier Source: org_study_id
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