Residual Platelet Activity Despite Aspirin Utilization in Coronary Heart Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2012-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to compare the response to aspirin in the acute phase with the late phase of an acute coronary syndrome.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Platelet Hyperreactivity to Aspirin and Stroke

NCT00766896

Stroke Cerebral Infarction Cardiovascular Diseases +5 more

COMPLETED PHASE4

ACCEL-LOADING-ACS Study

NCT01354808

Platelet Aggregation Inhibitors Anti-inflammatory Agent Myocardial Reperfusion Injury

COMPLETED PHASE4

Platelet Function in Patients With an Acute Coronary Syndrome

NCT01992484

Acute Coronary Syndrome (ACS)

UNKNOWN

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

NCT01952392

Acute Coronary Syndrome

COMPLETED

Pharmacodynamic Effects of Dabigatran in Patients on Dual Antiplatelet Therapy

NCT01852162

Coronary Artery Disease

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study is to compare, in the same population, the response to aspirin in the initial phase (first 48 hours) with the late phase (after 3 months of discharge)of a non ST elevation acute coronary syndrome (angina or acute myocardial infarction).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Coronary Heart Disease Non ST-elevation Acute Coronary Syndromes

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

First 48 hours

Patients in the first 48 hours of non ST-elevation acute coronary syndromes.

No interventions assigned to this group

3 months after discharge

Patients with 3 months after hospital discharge for non ST-elevation acute coronary syndromes.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age ≥ 18 years
* Confirmed diagnosis of acute coronary syndrome without ST segment elevation, in the first 48 hours after the onset of the clinical symptoms
* Regular use of aspirin for at least seven days.

Exclusion Criteria

* Previous use, in the last 7 days, of another antiplatelet agent than aspirin
* Use of antivitamin K in the last 3 weeks
* Hemoglobin \< 10g/dL and / or hematocrit \< 30% or \> 50%, platelets count \< 100.000/mm3 or \> 500.000/mm3, creatinine clearance \< 30 mL / minute
* Killip class III or IV
* Need for vasopressor or inotropic parenteral medication at inclusion in the study
* Percutaneous coronary intervention within 30 days or CABG in the last 90 days prior to study entry
* Current malignancy
* Hematologic diseases
* Refusal to sign the inform consent form
* Unable to attend the second visit (follow-up) for any reason except for death

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No