The Concomitant Cryomaze Procedure Using Nitreous Oxide Cryoprobe: Comparison With Argon Based Cryoprobe

NCT ID: NCT01812356

Last Updated: 2017-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2016-12-31

Brief Summary

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The aim of this study is compare the surgical convenience and early and long-term outcomes of cryomaze procedure using nitrous oxide with using Argon gas.

The investigators will analyze the pathologic findings of atrial tissue after cryoablation using two probes and early and long-term outcomes with Holter monitoring. Atrial fibrillation burden 3 months and 1 year postoperatively and atrial activity will be checked.

Detailed Description

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The investigators have used the Medtronic ATS cryoprobe (Argon based) since 2009 for cryomaze procedure for treatment of atrial fibrillation combined with valvular heart disease.

However, sometimes, it was inconvenient due to excess flexibility, wide lesion related to excess low temperature and time-consuming detachment from atrium after cryoablation. The investigators introduced Atricure cryoprobe (Nitreos Oxide based) in hope of overcoming these shortcomings of ATS probes last year.

Up to date, the investigators have been satisfactory in terms of the surgical convenience. On the other hand, we have the questionability of transmural lesion of Atricure probe because of the higher temperature of Atricure probe compared with ATS probe.

The aim of this study is compare the surgical convenience and early and long-term outcomes of cryomaze procedure using nitrous oxide with using Argon gas.

The investigators will analyze the pathologic findings of atrial tissue after cryoablation using two probes and early and long-term outcomes with Holter monitoring. Atrial fibrillation burden 3 months and 1 year postoperatively and atrial activity will be checked.

Conditions

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Atrial Fibrillation Valve

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Argon gas probe

Cryomaze procedure using Argon gas probe

Group Type EXPERIMENTAL

Cryomaze procedure using Argon

Intervention Type DEVICE

Cryomaze procedure using Argon

Nitrous oxide probe

Cryomaze procedure using Nitrous oxide probe

Group Type ACTIVE_COMPARATOR

Cryomaze procedure using Nitrous oxide

Intervention Type DEVICE

Cryomaze procedure using Nitrous oxide

Interventions

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Cryomaze procedure using Nitrous oxide

Cryomaze procedure using Nitrous oxide

Intervention Type DEVICE

Cryomaze procedure using Argon

Cryomaze procedure using Argon

Intervention Type DEVICE

Other Intervention Names

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Atricure cryoprobe ATS medtronic probe

Eligibility Criteria

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Inclusion Criteria

* requiring concomitant maze operation with valve surgery (persistent atrial fibrillation)
* between 18 and 75 years old

Exclusion Criteria

* previous cardiac surgery
* Behcet disease
* Takayasu's arteritis
* Infective endocarditis
* Congenital heart disease
* left atrial size over 80mm
* moderate or greater functional tricuspid regurgitation
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pyo Won Park, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2012-11-088

Identifier Type: -

Identifier Source: org_study_id

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