The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

NCT ID: NCT01807832

Last Updated: 2013-03-08

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-03-31
• Study Completion Date: 2013-12-31

Brief Summary

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Detailed Description

Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Conditions

Chronic Cough

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

chronic cough

Capsaicine challenge in chronic cough patients

Group Type: OTHER

capsaicin challenge

Intervention Type: OTHER

Interventions

capsaicin challenge

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion Criteria

• Diagnosis of respiratory or lung diseases of any kind

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tel-Aviv Sourasky Medical Center

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

TASMC-13-LF-0695-CTIL

Identifier Type: -

Identifier Source: org_study_id