Stimulation of the Larynx to Treat Unexplained Chronic Cough
NCT ID: NCT05273190
Last Updated: 2025-08-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2021-07-13
2027-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Vibrotactile Stimulation
Vibrotactile Stimulation
Small electric motors, similar to a vibrating cell phone or gaming joystick, deliver vibration to the throat. Participants will assess cough symptoms throughout the study period.
Interventions
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Vibrotactile Stimulation
Small electric motors, similar to a vibrating cell phone or gaming joystick, deliver vibration to the throat. Participants will assess cough symptoms throughout the study period.
Eligibility Criteria
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Inclusion Criteria
* \>8 weeks of cough
* Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale
* Ability to provide informed consent and independently complete questionnaires
* Ability to read and speak English
Exclusion Criteria
* Currently doing speech therapy for cough
* Contraindications to safe or effective VTS device use
* No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis)
* Untreated carotid disease
* BMI \> 40 (for transmission of VTS through soft tissue)
* Current or recent (quit \< 3 months ago) smoking
* Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
* History of known or suspected aspiration pneumonia
* Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD)
* Diagnosis or clinical suspicion of interstitial lung disease (ILD)
* Unmanaged reflux
* Unmanaged allergies/postnasal drip
18 Years
88 Years
ALL
No
Sponsors
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University of Minnesota
OTHER
Responsible Party
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Principal Investigators
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Stephanie Misono
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
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University of Minnesota
Minneapolis, Minnesota, United States
Countries
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Central Contacts
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Clinical Research Coordinators Ashley Ramaker, MS or colleagues
Role: CONTACT
Facility Contacts
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Other Identifiers
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ENT-2020-28903
Identifier Type: -
Identifier Source: org_study_id
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