Influence of Profound Muscle Relaxation on Muscle Trauma and Postoperative Pulmonary Function
NCT ID: NCT01804933
Last Updated: 2013-03-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
72 participants
INTERVENTIONAL
2012-07-31
2013-08-31
Brief Summary
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This study, however, is designed to test the hypothesis that profound neuromusclular blockade reduces muscle trauma caused by self-retaining retractor and thus cut down postoperative analgesic requirement.On the other hand,profound muscle relaxation can decrease postoperative diaphragmatic dysfunction and abdominal muscle trauma, which can improve postoperative pulmonary function.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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conventional neuromuscular blockade
No rocuronium will be administered intraoperatively unless there is surgeons' complain or patients movement
No interventions assigned to this group
optimal neuromuscular blockade
Rocuronium dose will be infused to maintain depth of NMB at TOF count 1 intraoperatively
profound neuromuscular blockade
Rocuronium dose will be infused to maintain a depth of NMB to PTC 1\~2 intraoperatively
profound neuromuscular blockade
Rocuronium dose will be infused to maintain a depth of NMB to PTC 1\~2 intraoperatively
profound neuromuscular blockade
Rocuronium dose will be infused to maintain a depth of NMB to PTC 1\~2 intraoperatively
Interventions
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profound neuromuscular blockade
Rocuronium dose will be infused to maintain a depth of NMB to PTC 1\~2 intraoperatively
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* history of malignant hyperthemia
* allergy to medications used during general anesthesia
18 Years
65 Years
ALL
No
Sponsors
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Ying Xiao
OTHER
Responsible Party
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Ying Xiao
Associate Professor
Principal Investigators
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Ying Xiao, MD, PhD
Role: STUDY_DIRECTOR
First Affiliated Hospital, Sun Yat-Sen University
Locations
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The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Other Identifiers
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伦审[2012]326号
Identifier Type: -
Identifier Source: org_study_id
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