Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement
NCT ID: NCT01804283
Last Updated: 2013-03-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
8 participants
INTERVENTIONAL
2013-03-31
Brief Summary
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2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.
3. Downstream effectors would also be affected.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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CON
Patients undergoing double valve replacement (aortic and mitral).
double valve replacement
The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves.
heart-lung machine
The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation.
Aortic cross-clamp
a surgical instrument used in cardiac surgery to clamp the aorta
IPO
Patients undergoing double valve replacement (aortic and mitral) with ischemic postconditioning.
ischemic postconditioning
multiple brief ischemic-reperfusion episodes immediately after sustained ischemic insult
Postconditioning was started at 30 s after aortic cross declamping, and the aorta was re-clamped for 30 s rendering global myocardial ischemia. Meanwhile aortic root suction was established during aortic re-clamping, and thereafter, the aortic clamp was released for 30 s for full myocardial reperfusion. The cycle was repeated three times after cardioplegic arrest.
double valve replacement
The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves.
heart-lung machine
The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation.
Aortic cross-clamp
a surgical instrument used in cardiac surgery to clamp the aorta
Interventions
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ischemic postconditioning
multiple brief ischemic-reperfusion episodes immediately after sustained ischemic insult
Postconditioning was started at 30 s after aortic cross declamping, and the aorta was re-clamped for 30 s rendering global myocardial ischemia. Meanwhile aortic root suction was established during aortic re-clamping, and thereafter, the aortic clamp was released for 30 s for full myocardial reperfusion. The cycle was repeated three times after cardioplegic arrest.
double valve replacement
The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves.
heart-lung machine
The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation.
Aortic cross-clamp
a surgical instrument used in cardiac surgery to clamp the aorta
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* pulmonary, renal, or hepatic failure
* infective valve disease
* valve disease with coronary artery disease
* hypertension
* emergency and reoperations
* received aspirin,corticosteroids, or statin preoperatively
* received preoperative inotropic support
20 Years
ALL
No
Sponsors
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Central South University
OTHER
Responsible Party
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Luo Wanjun
Prof.
Principal Investigators
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Wanjun Luo, MD
Role: PRINCIPAL_INVESTIGATOR
Xiangya Hospital of Central South University
Locations
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Xiangya Hospital
Changsha, Hunan, China
Countries
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Facility Contacts
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References
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Gao Y, Huang R, Chen R, Li J, Luo W. Ischemic postconditioning altered microRNAs in human valve replacement. J Surg Res. 2016 Jan;200(1):28-35. doi: 10.1016/j.jss.2015.07.010. Epub 2015 Jul 10.
Other Identifiers
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CmiR-001
Identifier Type: -
Identifier Source: org_study_id
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