Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms

NCT ID: NCT01801007

Last Updated: 2021-03-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

145 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2018-01-31

Brief Summary

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The purpose of this study is to evaluate the safety and effectiveness of the MicroVention Flow Redirection Intraluminal Device (FRED) system when used in the treatment of wide-necked intracranial aneurysms.

Detailed Description

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Conditions

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Intracranial Aneurysms

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

FRED
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Flow Re-Direction Endoluminal Device

Group Type OTHER

Flow Re-Direction Endoluminal Device (FRED)

Intervention Type DEVICE

Interventions

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Flow Re-Direction Endoluminal Device (FRED)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Participant whose age ≥ 22 and ≤75 years
* Participant has single target aneurysm located in the internal carotid artery
* Participant sign and date an IRB/EC approved informed consent prior initiation of any study procedures

Exclusion Criteria

* Participant who suffers from an intracranial hemorrhage in the last 30 days
* Participant who suffers from a subarachnoid hemorrhage in the last 60 days
* Participant with symptomatic extracranial mass or currently undergoing radiation therapy for tumor of the head and neck region
* Participant who is pregnant or breastfeeding
* Participant has an arteriovenous malformation (AVM) in the area of the target aneurysm
Minimum Eligible Age

22 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Microvention-Terumo, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cameron McDougall, MD

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Locations

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St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

Site Status

Swedish Medical Center / RIA

Englewood, Colorado, United States

Site Status

Lyerly Neurosurgery

Jacksonville, Florida, United States

Site Status

Emory University

Atlanta, Georgia, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

Norton Neuroscience Institute

Louisville, Kentucky, United States

Site Status

The Johns Hopkins Hospital

Baltimore, Maryland, United States

Site Status

Tufts Medical Center

Boston, Massachusetts, United States

Site Status

Abbott Northwestern Hospital

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Washington University

St Louis, Missouri, United States

Site Status

Capital Health Hospital

Trenton, New Jersey, United States

Site Status

Albany Medical Center

Albany, New York, United States

Site Status

University at Buffalo

Buffalo, New York, United States

Site Status

North Shore University Hospital

Manhasset, New York, United States

Site Status

Mount Sinai Health System

New York, New York, United States

Site Status

Stony Brook University Medical Center

Stony Brook, New York, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Methodist University Hospital

Memphis, Tennessee, United States

Site Status

Baylor Saint Luke Medical Center

Houston, Texas, United States

Site Status

The Methodist Hospital

Houston, Texas, United States

Site Status

Institute of Biomedical Research and Innovation

Kobe, , Japan

Site Status

Countries

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United States Japan

References

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McDougall CG, Diaz O, Boulos A, Siddiqui AH, Caplan J, Fifi JT, Turk AS, Kayan Y, Jabbour P, Kim LJ, Hetts SW, Cooke DL, Dowd CF. Safety and efficacy results of the Flow Redirection Endoluminal Device (FRED) stent system in the treatment of intracranial aneurysms: US pivotal trial. J Neurointerv Surg. 2022 Jun;14(6):577-584. doi: 10.1136/neurintsurg-2021-017469. Epub 2021 Jul 19.

Reference Type DERIVED
PMID: 34282038 (View on PubMed)

Provided Documents

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Document Type: Statistical Analysis Plan

View Document

Document Type: Study Protocol

View Document

Other Identifiers

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G120111

Identifier Type: OTHER

Identifier Source: secondary_id

CL12001

Identifier Type: -

Identifier Source: org_study_id

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