Open Label, 4 Week Study of ITCA 650 in Adults With Type 2 Diabetes

NCT ID: NCT01798264

Last Updated: 2013-05-17

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2009-05-31

Brief Summary

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evaluate the safety and tolerability of ITCA 650 in subjects with type 2 diabetes mellitus.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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10 mcg./day

ITCA 650 (exenatide in DUROS)

Group Type EXPERIMENTAL

ITCA 650 (exenatide in DUROS)

Intervention Type DRUG

20 mcg/day

ITCA 650 (exenatide in DUROS)

Group Type EXPERIMENTAL

ITCA 650 (exenatide in DUROS)

Intervention Type DRUG

40 mcg/day

ITCA 650 (exenatide in DUROS)

Group Type EXPERIMENTAL

ITCA 650 (exenatide in DUROS)

Intervention Type DRUG

80 mcg/day

ITCA 650 (exenatide in DUROS)

Group Type EXPERIMENTAL

ITCA 650 (exenatide in DUROS)

Intervention Type DRUG

Interventions

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ITCA 650 (exenatide in DUROS)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* type 2 diabetes \>6 months
* stable diet \& exercise, metformin, TZD or met + TZD HbA1c \>6.5% \<10.0%

Exclusion Criteria

* prior treatment with exenatide
* history of pancreatitis
* history of medullary thyroid cancer or multiple endocrine neoplasia 2
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Intarcia Therapeutics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Miami Gardens, Florida, United States

Site Status

Medpace Clinical Pharmacology Unit

Cincinnati, Ohio, United States

Site Status

dGd Research

San Antonio, Texas, United States

Site Status

Countries

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United States

References

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Henry RR, Logan D, Alessi T, Baron MA. A randomized, open-label, multicenter, 4-week study to evaluate the tolerability and pharmacokinetics of ITCA 650 in patients with type 2 diabetes. Clin Ther. 2013 May;35(5):634-645.e1. doi: 10.1016/j.clinthera.2013.03.011. Epub 2013 Apr 8.

Reference Type DERIVED
PMID: 23578605 (View on PubMed)

Other Identifiers

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ITCA 650-CLP-01

Identifier Type: -

Identifier Source: org_study_id

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