Exenatide and Basal Insulins Use in the Real Setting: an Observational Study in Patients With Type 2 Diabetes

NCT ID: NCT01060059

Last Updated: 2015-04-09

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

888 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-30

Study Completion Date

2012-05-31

Brief Summary

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Although the efficacy and safety profile of exenatide has been well established, few data exist on the real world results of exenatide treatment in specific populations and clinical settings. This study is intended to fill this gap through observing and collecting prospective data from a population of Italian patients initiating treatment with either exenatide or basal insulin formulations after failure to achieve glycemic control with oral antihyperglycemic agents (OHA).

Observational studies represent noninterventional research; therefore, this study does not involve randomization of patients to particular comparator arms or therapies. The term "noninterventional" means that the healthcare providers decisions regarding the proper treatment and care of the patient are made in the course of normal clinical practice. Patients enrolled in this study are enrolling for the collection of their data on observations made during normal clinical practice.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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exenatide

The targeted population consists of adult patients with type 2 Diabetes Mellitus unable to achieve the desired level of glycemic control while using oral anti-hyperglycemic agents and who initiate treatment with exenatide.

exenatide

Intervention Type DRUG

subcutaneous injection, 5mcg or 10mcg, twice a day

basal insulin

The targeted population consists of adult patients with type 2 Diabetes Mellitus unable to achieve the desired level of glycemic control while using oral anti-hyperglycemic agents and who initiate treatment with basal insulin.

basal insulin

Intervention Type DRUG

subcutaneous injection, dosing according to physician's clinical judgment

Interventions

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exenatide

subcutaneous injection, 5mcg or 10mcg, twice a day

Intervention Type DRUG

basal insulin

subcutaneous injection, dosing according to physician's clinical judgment

Intervention Type DRUG

Other Intervention Names

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BYETTA

Eligibility Criteria

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Inclusion Criteria

1. Are inadequately controlled with single or multiple OHA as evidenced by an HbA1c \> 7.0%
2. Have presented during the routine course of care and, together with their physician, have decided to initiate treatment with either exenatide twice daily or conventional insulin therapy with basal insulin (insulin glargine, detemir, protaminated insulin lispro, protaminated human insulin) added to the existing treatment with OHA
3. Have not been treated with GLP-1 receptor agonist for more than 7 consecutive days within 3 months before entering the study
4. Have not been treated with insulins for more than 7 consecutive days within last 3 months or more than 3 months in the course of the disease
5. Are not simultaneously participating in another study which includes an investigational drug or procedure at study entry
6. Have been fully informed and given their written consent for use of their data
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Malone, MD

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Research site

Acquaviva delle Fonti, , Italy

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Anzio, , Italy

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Bassano del Grappa, , Italy

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Bologna, , Italy

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Brindisi, , Italy

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Cagliari, , Italy

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Campi Salentina, , Italy

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Casarano, , Italy

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Caserta, , Italy

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Cesena, , Italy

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Chieri, , Italy

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Cisternino, , Italy

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Copertino, , Italy

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Cremona, , Italy

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Distretto Vittoria, , Italy

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Fermo, , Italy

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Ferrara, , Italy

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Fidenza, , Italy

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Florence, , Italy

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Forlì, , Italy

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Genova, , Italy

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Germaneto, , Italy

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Lecce, , Italy

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Livorno, , Italy

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Lucca, , Italy

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Manfredonia (Le), , Italy

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Mariano Comense, , Italy

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Messina, , Italy

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Milan, , Italy

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Monza, , Italy

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Napoli, , Italy

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Novara, , Italy

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Olbia, , Italy

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Palermo, , Italy

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Palmi, , Italy

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Parma, , Italy

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Pavia, , Italy

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Pisa, , Italy

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Potenza, , Italy

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Rimini, , Italy

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Roma, , Italy

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Rossano Scalo, , Italy

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Salerno, , Italy

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San Giovanni Rotondo, , Italy

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Schio, , Italy

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Sesto San Giovanni, , Italy

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Siena, , Italy

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Treviso, , Italy

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Trieste, , Italy

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Varese, , Italy

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Countries

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Italy

Other Identifiers

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H8O-IT-B014

Identifier Type: -

Identifier Source: org_study_id

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