The Histological Analysis in Renal Transplantation Patients With Deterioration of Graft Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-05-31

Study Completion Date

2013-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Identify the cause of chronic allograft dysfunction using a combination of comprehensive clinical and histologic information in Chinese renal transplant recipients, then to identify the position of CNI nephrotoxicity in CAD.Chronic allograft dysfunction reflects the dual impact of both immunologic and nonimmunologic (primarily calcineurin inhibitor \[CNI\]nephrotoxicity) injury. In previous, CNI nephrotoxicity is overstated and considered one of the major causes of CAD, however, recently there has been found most death-censored graft losses to be the result of alloimmune or autoimmune injury, with only a minority of cases attributable to CNI toxicity. Unfortunately, Situation of objective CNI toxicity in CAD in China is not well analyzed. To improve perception of Neo safety with more local evidence, we want to do a retrospective study to identify the cause of chronic allograft dysfunction using a combination of comprehensive clinical and histologic information in Chinese renal transplantation recipients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Histology of Implantation Biopsies and Kidney Allograft Outcomes

NCT03155763

Kidney Graft Dysfunction

COMPLETED

Proteogenomic Monitoring and Assessment of Kidney Transplant Recipients

NCT01531257

Acute Rejection (AR) of Transplanted Kidney Chronic Allograft Nephropathy (CAN) Interstitial Fibrosis (IF) +1 more

RECRUITING

To Explore the Application Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function and Systemic Metabolism After Renal Transplantation

NCT07145944

Kidney Transplant Failure and Rejection Transplantation, Kidney Kidney Transplant Dysfunction

NOT_YET_RECRUITING

Catalytic Antibodies to Predict Uninvasively Late Transplant Failure

NCT02843295

Renal Transplantation

COMPLETED NA

Renal Allograft Fibrosis Study

NCT05058170

Renal Allograft Fibrosis

ENROLLING_BY_INVITATION

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Allograft Dysfunction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 years of age or older
* Kidney transplant recipients, only including recipients of living-donor grafts
* Underwent an allograft biopsy between January 2005 and December 2011 because of developing deterioration of graft function\*.

* Deterioration of function was defined as (1) an unexplained and persistent greater than or equal to 25% increase of CR over baseline (in the absence of potential confounding factors) or (2) new onset proteinuria (defined as albumin/CR ratio ≥0.2 or a protein/CR ratio \>0.5).

Exclusion Criteria

* Multiple organ transplants, prior transplant with any other organ or tissue
* Patients who did not have the information regarding the pathological diagnosis
* Patients who did not have the histological sections of the allograft biopsy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No