Nephronic Reduction After Neonatal Acute Renal Failure in Preterm

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2013-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure. The investigators hypothesize that signs of nephronic reduction would appear earlier in former preterm with neonatal acute renal failure than in control preterm infants.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Nephrocalcinosis in Very Low Birth Weight Infants

NCT04860583

Infant; Premature, Light-For-Dates

COMPLETED

Urinary Creatinin/Protein Ratio in Preterms

NCT04608279

Preterm Infant Renal Failure

COMPLETED

Urinary Creatinine Excretion Time in the Neonatal Period

NCT05813730

Renal Function

RECRUITING NA

Plasma Protein Levels and Very Preterm Birth

NCT02007902

Very Preterm Infants

COMPLETED

Urine Biomarkers for Renal Function Monitoring in Preterm Infants

NCT02813109

Premature Infant

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

50 former preterm infants who presented acute renal failure will be evaluated between 3 to 10 years.

They will be compared to 25 control former preterm infants without renal dysfunction for signs of nephronic reduction.

At inclusion, in order to analyse renal function, all infants will have blood sampling, renal echography and blood pressure measurement. Urine sample will also be collected.

Two months later, parents will be informed on the results.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neonatal Acute Renal Failure in Preterm

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

cases with neonatal acute renal failure in preterm

Group Type EXPERIMENTAL

renal echography

Intervention Type OTHER

renal echography to analyse the kidney

Blood sampling

Intervention Type OTHER

Blood sampling to analyse different parameters of renal function

collection of an urine sample

Intervention Type OTHER

Collection of an urine sample to perform analysis of renal function parameters

Blood pressure measurement

Intervention Type OTHER

controls without neonatal acute renal failure in preterm

Group Type OTHER

renal echography

Intervention Type OTHER

renal echography to analyse the kidney

Blood sampling

Intervention Type OTHER

Blood sampling to analyse different parameters of renal function

collection of an urine sample

Intervention Type OTHER

Collection of an urine sample to perform analysis of renal function parameters

Blood pressure measurement

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

renal echography

renal echography to analyse the kidney

Intervention Type OTHER

Blood sampling

Blood sampling to analyse different parameters of renal function

Intervention Type OTHER

collection of an urine sample

Collection of an urine sample to perform analysis of renal function parameters

Intervention Type OTHER

Blood pressure measurement

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* For both group of cases (50 infants having presented acute renal failure in preterm) AND group of control cases (25 infants without this) :former preterm infant born before 33 weeks of gestational age between january 2003 and june 2010 and hospitalized in the neonatal intensive care unit of Nantes University Hospital.
* Specific to cases: neonatal acute renal failure: serum creatinine\>130 micromol/l from the third day of life.
* Control cases: no such renal dysfunction

Exclusion Criteria

* no parental consent
* other causes of renal failure: congenital uropathy, congenital nephropathy
* congenital cardiopathy, polymalformative syndrome

Minimum Eligible Age

3 Years

Maximum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes