Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment

NCT ID: NCT01771757

Last Updated: 2014-07-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 24 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-12-31
• Study Completion Date: 2014-07-31

Brief Summary

The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation. On the basis of measurements in the hypobaric chamber this hypothesis should be verified.

Detailed Description

Conduct a pilot study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled, reduced ambient and oxygen partial pressure in the pressure chamber of the Aeromedical Institute FAI in Dübendorf, Switzerland. Obtaining evidence of the adaptation behavior of the retinal vascular system in controlled, short-term hypoxic changes.

Conditions

Healthy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• healthy

Exclusion Criteria

• eye diseases
• systemic diseases
• term medication (except contraceptives)
• pregnancy
• allergies to the ingredients Alcain, Tropicamide and Phenylephrine
• blood pressure levels except standard (<60 /> 140 mmHg)
• oxygen saturation (SO2) <90%

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Josef Flammer, MD

Role: STUDY_DIRECTOR

University of Basel, Dept. of Ophthalmology

Locations

University of Basel, Dept. of Ophthalmology

Basel, , Switzerland

Countries

Switzerland

Other Identifiers

USB-2011-327

Identifier Type: -

Identifier Source: org_study_id