Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy
NCT ID: NCT01758120
Last Updated: 2017-07-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
135 participants
INTERVENTIONAL
2012-12-31
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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prednisone plus cyclophosphamide
prednisone plus cyclophosphamide: prednisone(0.5mg/kg/day\*6 months) plus cyclophosphamide(1g intravenous use,per 1 month\*6months)
prednisone plus cyclophosphamide
1. prednisone plus cyclophosphamide: prednisone(0.5mg/kg/day\*6 months) plus cyclophosphamide(1g intravenous use,per 1 month\*6months);
2. supportive care,including ACE-I or ARBs and blood pressure control
prednisone alone
prednisone alone: prednisone(0.5mg/kg/day\*6 months)
Prednisone alone
1. prednisone alone: prednisone(0.5mg/kg/day\*6 months);
2. supportive care,including ACE-I or ARBs and blood pressure control
Interventions
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prednisone plus cyclophosphamide
1. prednisone plus cyclophosphamide: prednisone(0.5mg/kg/day\*6 months) plus cyclophosphamide(1g intravenous use,per 1 month\*6months);
2. supportive care,including ACE-I or ARBs and blood pressure control
Prednisone alone
1. prednisone alone: prednisone(0.5mg/kg/day\*6 months);
2. supportive care,including ACE-I or ARBs and blood pressure control
Eligibility Criteria
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Inclusion Criteria
* 18-70 years old;
* elevated serum Creatinine and less than 3.0mg/dl;
* with a written consent from participants to receive prednisone and/or cyclophosphamide
Exclusion Criteria
* contraindications for the treatment of prednisone and/or cyclophosphamide;
* any treatment with steroids or immunosuppressive drugs prior to this study;
* acute deterioration of renal function(including those of glomerular origin)
18 Years
70 Years
ALL
No
Sponsors
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Guangdong Provincial People's Hospital
OTHER
Responsible Party
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Wei Shi
clinical professor
Principal Investigators
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wei shi, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Guangdong Provincial People's Hospital
Locations
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Guangdong General Hospital
Guangzhou, Guangdong, China
Countries
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Other Identifiers
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GGH2012-36
Identifier Type: -
Identifier Source: org_study_id
GGH2012-36
Identifier Type: OTHER
Identifier Source: secondary_id
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